A new type of insulin delivery system capable of better self-regulating the release of insulin was reported in this study. This insulin delivery system was made of a low crosslinked insulin-imprinted hydrogel that exhibited pH-dependent interpolymer interactions between poly(methacrylic acid) (PMAA) and poly(ethylene glycol) (PEG). At acidic conditions (such as pH 3.5), this delivery system res...

In an answer to the challenge of enzymatic instability and low oral bioavailability of proteins/peptides, a new type of drug-delivery vesicle has been developed. The preparation, based on sodium dodecyl sulfate (SDS) and β-cyclodextrin (β-CD) embedded in chitosan gel, was used to successfully deliver the model drug-insulin. The self-assembled SDS/β-CD vesicles were prepared and characterized by...

thermo-sensitive polymers were prepared by graft copolymerization of gelatin with n-isopropylacrylamide via gamma radiation. characterization of polymers such as dsc analysis, swelling in different ratios and cell assays were investigated. dsc and solubility analysis showed gelatin and nipaam monomer were grafted via gamma radiation successfully. results show swelling of samples increased with ...

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of Glipizide (G) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. The release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also e...

A simple two-step method for fabricating poly(ethylene glycol) (PEG) hydrogel-based microreactors and microsensors within microfluidic channels is described. The intrachannel micropatches contain either a dye, which can report the pH of a solution within a fluidic channel, or enzymes that are able to selectively catalyze specific reactions. Analytes present within the microfluidic channel are a...

ABSTRACT Biomaterials having stimuli response are interesting in the biomedical field. This paper reports about swelling response and internalstructural of biomineralized (CaCO3) polyvinylpyrrolidone (PVP) carboxymethylcellulose (CMC) hydrogel having various thicknesses (0.1-0.4 mm). Samples were tested in aqueous solution using temperature ranges from 10 to 40 °C; pH varies from 4 to 9, time 6...

the main objective of this study was to investigate biocompatibility and provide in vivo pharmacological and toxicological evidence for further investigation of the possibility of ph sensitive ion exchange resin microsphere for clinical utilizations. acute toxicity study and general pharmacological studies were conducted on the ph sensitive ion exchange resin microsphere we prepared. the genera...

Like charges stabilize emulsions, whereas opposite charges break emulsions. This is the fundamental principle for many industrial and practical processes. Using micrometer-sized pH-sensitive polymeric hydrogel particles as emulsion stabilizers, we prepare emulsions that consist of oppositely charged droplets, which do not coalesce. We observe noncoalescence of oppositely charged droplets in bul...

Improving the therapeutic efficacy and reducing systemic side effects of drugs is an important aspect in chemotherapy. The strategy presented here is the use of cisplatin loaded, temperature-sensitive, hydrogel nanoparticles (CisPt-NPs) and their ability to deliver and release chemodrugs selectively, based on thermal stimuli. The specially synthesized CisPt-NPs show a temperature-dependent incr...

Microparticles of novel, bioadhesive graft copolymers of polymethacrylic acid and polyethylene glycol (P(MAA-g-EG)) were prepared. The aims of this study were to investigate the uptake and release kinetics of budesonide from P(MAA-g-EG) in vitro as well as the pharmacokinetics following nasal administration of the polymer contained budesonide. The loading of budesonide into the pH-sensitive pol...