Eflornithine is not official in any of the pharmacopoeias, the literarture survey did not reveal any analytical method for quantitative estimation of eflornithine. Thus there is a need for the development of newer effective, sensitive, accurate and economical methods of analysis for quantitative estimations of eflornithine as an active pharmaceutical ingredient. The aim of this work was to deve...

Pharmaceutical cocrystals of nonsteroidal anti-inflammatory drugs diflunisal (DIF) and diclofenac (DIC) with theophylline (THP) were obtained, and their crystal structures were determined. In both of the crystal structures, molecules form a hydrogen bonded supramolecular unit consisting of a centrosymmetric dimer of THP and two molecules of active pharmaceutical ingredient (API). Crystal lattic...

Pharmaceutical co-crystallisation is emerging as a possible alternative to polymorphs, salts and solvates in the modification of an active pharmaceutical ingredient (API) during dosage form. It may alter the physico-chemical properties of the API (e.g. melting point and solubility), and also have intellectual property implications. Traditionally, co-crystallisation research has involved robust ...

Although most pharmaceutical heparin used today is obtained from porcine intestine, heparin has historically been prepared from bovine lung and ovine intestine. There is some regulatory concern about establishing the species origin of heparin. This concern began with the outbreak of mad cow disease in the 1990s and was exacerbated during the heparin shortage in the 2000s and the heparin contami...

Introduction Most commercially-available dry powder inhaler (DPI) formulations utilize a carrier-based formulation concept. Utilizing a mixing process, micronized active pharmaceutical ingredient (API) particles are attached to the surface of larger excipient particles. Multiple studies list excipients such as mannitol, glucose monohydrate, trehalose, dextrose, maltose, sorbitol and maltitol fo...

Panthenol is the alcohol analogue of panthothenic acid, known as vitamin B5, which is required for the biosynthesis of coenzyme A in cells. This compound exists as two stereoisomers, D-pathenol and L-panthenol, only the former being biologically active (1). It is a common ingredient in pharmaceutical products, for example in topical treatments for rhinitis, conjunctivitis, sunburn, and wounds, ...

INTRODUCTION Antibodies now have a critical role in both therapeutics and diagnostics areas of medicine and research. The market is expected to grow at a CAGR of 8% or more for several years and reach 90B USD by 2017 (Figure 1). There are many challenges to bringing a new active pharmaceutical ingredient to market. Of these challenges the need to reduce total cost of development and decrease th...

As a part of an integrated quality concept in drug development, the multidimensional evaluation of impurity profiles by LC-MS/MS is presented for quetiapine--an active pharmaceutical ingredient (API). LC-UV is commonly employed for the determination of impurities and degradation products. In this work LCMS/MS technique is proposed as a modern alternative for the characterization of these compou...

New chromatographic-densitometric assay was developed for identification and determination of risperidone in pharmaceutical formulations. Thin-layer chromatographic plates (TLC-F254) as a stationary phase and n-butanol-acetic acid-water (12:3:5 v/v/v) as a mobile phase were used for separation. Densitometric measurements were done for all constituents at lambda = 280 nm. A decrease in stability...