Schiff bases are versatile ligands and known to be synthesized from the condensation of an amino compound with carbonyl compounds. These compounds along with their metal complexes are considered to be an important as catalysts in various biological processes. Also Schiff base complexes are gaining popularity among the various industries including polymers, dyes and pharmaceutical. This review s...

Benzyl alcohol used as the sample preparation solvent in the determination of residual solvents in pharmaceutical bulks yielded benzene, toluene, and benzaldehyde on capillary gas chromatography (GC) by sonication. The factors responsible for compounds generated are discussed. The quality of benzyl alcohol and the type of sonicator were not involved in the generation of benzene, toluene, and be...

The endophytic fungus is have rich source of secondary metabolites which act as biological active agent in the higher plants. The fungal derivatives play vital part in human life and their compounds are the source of drug for cancer, microbial and viral diseases. The natural compounds from the endophytes acts as growth inhibitor of plant pathogenic organism. Endophytes are rich sources of natur...

A total heart-cut LC-LC-MS technique is described for the analysis of pharmaceutical compounds. Utilizing ordinary LC-MS equipment, a standardized multi-dimensional, highly selective approach was developed. The system was developed on synthetic mixtures containing ten active pharmaceutical compounds. The methodology would be further deployed for the impurity characterization of batches of activ...

pharmaceutical industry is currently undergoing a transient phase with new orientation. loss of financial resources, presence of new therapeutic agents and increasing cost of research and development have called for a full.scale restructuring within the pharmaceutical industry to retain even the most basic competitiveness. the development of new technologies has been as one way out of the dilem...

The occurrence of 12 selected pharmaceutical compounds and pharmaceutical compound metabolites in sewage treatment works (STW) effluents and surface waters was investigated. The substances selected for the monitoring programme were identified by a risk ranking procedure to identify those substances with the greatest potential to pose a risk to the aquatic environment. STW final effluent and sur...

The statistics of drug development output and declining yield of approved medicines has been the subject of many recent reviews. However, assessing research productivity that feeds development is more difficult. Here we utilise an extensive database of structure-activity relationships extracted from papers and patents. We have used this database to analyse published compounds cumulatively linke...

Combinatorial Chemistry and Combinatorial Technology (CC/CT) are a new interdisciplinary field joining computerassisted combinatorial chemistry with automated parallel synthesis of chemical ìlibrariesî followed by automated screening. The main purpose of computer assisted combinatorial chemistry is to generate thousands structurally diverse compounds as libraries, maximising their diversity, wh...

phenolic and flavonoid compounds are secondary metabolites of plants which possess various activities such as anti-inflammatory, analgesic, anti-diabetes and anticancer effects. it has been established that these compounds can scavenge free radicals produced in the body. because of this ability, not only the plants containing phenolic and flavonoid compounds but also, the pure compounds are use...

Plants are recognized in the pharmaceutical industry for their broad structural diversity as well as their wide range of pharmacological activities. The biologically active compounds present in plants are called phytochemicals. These phytochemicals are derived from various parts of plants such as leaves, flowers, seeds, barks, roots and pulps. These phytochemicals are used as sources of direct ...