BACKGROUND Medicines use related challenges such as inadequate adherence, high levels of antimicrobial resistance and preventable adverse drug reactions have underscored the need to incorporate pharmaceutical services to help achieve desired treatment outcomes, and protect patients from inappropriate use of medicines. This situation is further constrained by insufficient numbers of pharmaceutic...

Introduction: The ischemically injured myocardium contains a mixture of viable and non-viable tissue post-myocardial infarction (MI); thus, a method to discern the various zones would be of great value in clinical management. The traditional approach in treatment attempts to salvage the viable peri-infarcted areas, by pharmaceutical intervention. A popular route of treatment is providing Angiot...

Randomised controlled trials (RCT) examining the effects of fish oil supplementation on cardiac outcomes have yielded varying results over time. Although RCT are placed at the top of the evidence hierarchy, this methodology arose in the framework of pharmaceutical development. RCT with pharmaceuticals differ in important ways from RCT involving fish oil interventions. In particular, in pharmace...

After the boom of pharmacological research during the 1950s, mainly as a result of the screening technique, the identification of active molecules, their reshaping by means of pharmaco-chemical drug design, and the creation of extremely efficacious and successful medicines, the pharmaceutical world sought a new source of inspiration. Such biota as the tropical forest, a quantity of plants credi...

Background: An Ebola outbreak of unparalleled size is currently affecting several countries in West Africa, and international efforts to control the outbreak are underway. However, the efficacy of these interventions, and their likely impact on an Ebola epidemic of this size, is unknown. Forecasting and simulation of these interventions may inform public health efforts. Methods: We use existing...

In some settings, steps are being taken to more fully integrate pharmacists in primary health care as a means of improving the public’s health and reducing drug-related iatrogenesis. Yet, evidence of improvement in health outcomes from pharmacists’ inputs is mixed; the diversity of research approaches and methodologies makes it difficult to reach an overall conclusion about it. A detailed revie...

BACKGROUND Exposure to indoor allergens contributes to increased asthma morbidity. The Inner-City Asthma Study, a randomized trial involving home environmental allergen and irritant remediation among children aged 6 through 11 years with moderate-to-severe asthma, successfully reduced asthma symptoms. A cost-effectiveness analysis can help stakeholders to evaluate the potential costs and benefi...

Pharmaceutical industry is currently undergoing a transient phase with new orientation. Loss of financial resources, presence of new therapeutic agents and increasing cost of research and development have called for a full.scale restructuring within the pharmaceutical industry to retain even the most basic competitiveness. The development of new technologies has been as one way out of the dile...

in this work, the optimization calculations were carried out on quetiapine hemifumarat, 4, and its analogues, 1-5. these calculations were carried out using the b3lyp/6-31g(d) level of theory. the dft calculations clarified a boat structure for dibenzothiazepine moiety of the molecule which piperazine moiety has a chair conformation. thermal energies (e), enthalpies (h), and free energies (g) o...