نتایج جستجو برای: pharmacodynamical drug interactions

تعداد نتایج: 948838  

Journal: :Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 2012

2013
Jin GU Hai-Bin CHEN

Drug-drug interaction and herb-drug interaction have been frequently reported when patients take propofol in combination with other important clinical drugs or herbs. Intestinal bacteria-catalyzed biotransformation process might significantly change the properties of compounds, such as the efficiency, toxicity, and the pharmacokinetic behaviours. The present study aims to investigate whether th...

Journal: :Journal of biomolecular screening 2009
Ben-Fillippo Krippendorff Roland Neuhaus Philip Lienau Andreas Reichel Wilhelm Huisinga

The potential of enzyme inhibition of a drug is frequently quantified in terms of IC(50) values. Although this is a suitable quantity for reversible inhibitors, concerns arise when dealing with irreversible or mechanism-based inhibitors (MBIs). IC(50) values of MBIs are time dependent, causing serious problems when aiming at ranking different compounds with respect to their inhibitory potential...

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