BAY38-4766 and BAY43-9695 are nonnucleosidic compounds with activities against human cytomegalovirus (HCMV). Two phenotypic assays were used to determine the drug susceptibilities of 36 HCMV clinical isolates to the BAY compounds and ganciclovir. Using either assay, both BAY compounds at a concentration of approximately 1 microM inhibited the replication of all 36 HCMV clinical isolates, includ...

Mesangial cell (MC) phenotypic transition is crucial for the progression of diabetic nephropathy. A major stimulus mediating high glucose-induced MC phenotypic transition is TGF-β1. Our current study focuses on microRNA-215 (miR-215) and investigates its role in TGF-β1-mediated MC phenotypic transition. Using real-time quantitative PCR (qRT-PCR) and northern blotting, we determined that the miR...

ABSTRACT In the period of planting second-season maize, there is high climatic instability with greater probability occurrence water deficit. This one factors that most cause reduction in maize grain yield. this context, aim was to identify stable, irrigation-responsive and drought-tolerant genotypes. The experiments were conducted Mococa / SP Tatuí SP, at Instituto Agronômico, two assays, unde...

Abstract Many inflammatory and autoimmune diseases present with specific organ manifestations. Understanding the immune process at site of inflammation may offer important insights into novel therapeutic strategies. To this end, we established a biology platform that allows us to develop deep understanding human tissue Treg behavior enable next generation therapeutics aimed activating these reg...

diabetes mellitus is one of the most common causes of neuropathy. although antioxidant and antidiabetic effects of the aqueous extract of purslane (portulaca oleracea) (aeop) have been demonstrated before by other researchers, we did not find any study that assessed the psychobiological effects of aeop in diabetes induced animals. thirty ovariectomized (ovx) female wistar rats were randomly div...

results low concentrations of agnps and short incubation times can have the maximum positive impact on the peroxidase activity, and in the present study the highest activity was seen at a concentration of 40 mg/l and two hours of incubation time. conclusions this study suggests that changes of enzyme activity can occur as a result of the effect of silver nanoparticles on enzyme conformation, in...

Epithelial-to-mesenchymal transitions (EMT) are strongly implicated in cancer dissemination. Intermediate states, arising from inter-conversion between epithelial (E) and mesenchymal (M) states, are characterized by phenotypic heterogeneity combining E and M features and increased plasticity. Hybrid EMT states are highly relevant in metastatic contexts, but have been largely neglected, partiall...

The "white-opaque" transition in Candida albicans was discovered in 1987. For the next fifteen years, a significant body of knowledge accumulated that included differences between the cell types in gene expression, cellular architecture and virulence in cutaneous and systemic mouse models. However, it was not until 2002 that we began to understand the role of switching in the life history of th...

Received: Revised: Accepted: 2014–02–18 2014–03–02 2014–03–02 The objective of the study was to characterize Staphylococcus aureus (S. aureus) isolated from human and animal clinical cases for their biofilm formation ability by genotypic and phenotypic methods. A total of 130 S. aureus strains isolated from human wound (n = 20), animal wound (n = 70) and animal mastitis (n = 40) cases were subj...