Abbreviations: PI3Ks: Phosphoinositide 3-kinases; PIKKs: Mammalian Target of Rapamycin; PKB: Protein Kinase B; PDK1: Phosphoinositide Dependent Kinase 1; mTOR: Mammalian Target of Rapamycin; DNA-PK: DNA dependent protein kinase; MTD: Maximum tolerated dose; EC50: 50% Effective dose; IC50: Half maximal inhibitory concentration; HGF: Hepatocyte Growth Factor; Hsp90: Heat Shock Protein 90; ATP: As...

Phosphoinositide signals regulate cell proliferation, differentiation, cytoskeletal rearrangement and intracellular trafficking. Hydrolysis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3, by inositol polyphosphate 5-phosphatases regulates synaptic vesicle recycling (synaptojanin-1), hematopoietic cell function [SHIP1(SH2-containing inositol polyphosphate 5-phosphatase-1)], renal cell function [OCRL (ocul...

During wound healing, release of ATP from platelets potentially exposes the epidermis to concentrations ofATP known to alter cellular functions mediated via changes in inositol trisphosphate (IP3) and intracellular calcium (Cai) levels. Therefore, we determined whether keratinocytes respond to ATP with a rise in Cai and IP3 and whether such increases are accompanied by a change in their prolife...

The membranes of eukaryotic cells create hydrophobic barriers that control substance and information exchange between the inside and outside of cells and between cellular compartments. Besides their roles as membrane building blocks, some membrane lipids, such as phosphoinositides (PIs), also exert regulatory effects. Indeed, emerging evidence indicates that PIs play crucial roles in controllin...