نتایج جستجو برای: phospholipase a1

تعداد نتایج: 43781  

Journal: :The Plant cell 2002
Takehide Kato Miyo Terao Morita Hidehiro Fukaki Yoshiro Yamauchi Michiko Uehara Mitsuru Niihama Masao Tasaka

In higher plants, the shoot and the root generally show negative and positive gravitropism, respectively. To elucidate the molecular mechanisms involved in gravitropism, we have isolated many shoot gravitropism mutants in Arabidopsis. The sgr2 and zig/sgr4 mutants exhibited abnormal gravitropism in both inflorescence stems and hypocotyls. These genes probably are involved in the early step(s) o...

Journal: :Biochimica et biophysica acta 1998
J M Pizauro M A Demenis P Ciancaglini F A Leone

Treatment with phosphatidylinositol-specific phospholipase C of rat osseous plate membranes released up to 90-95% of alkaline phosphatase, but a specific ATPase activity (optimum pH = 7.5) remained bound to the membrane. The hydrolysis of ATP by this ATPase was negligible in the absence of magnesium or calcium ions. However, at millimolar concentrations of magnesium and calcium ions, the membra...

Journal: :Cancer research 1977
M Record J Lloveras G Ribes D Douste-Blazy

A method is described for the localization and characterization of phospholipases A1 and A2 (EC3.1.1.4) in Krebs II ascites cells, particularly in the plasma membranes. Cells were lysed with a Dounce homogenizer in an isotonic sucrose medium. Plasma membranes sediment with mitochondria and lysosomes during subcellular fractionation and are finally isolated on a continuous sucrose gradient. The ...

Journal: :Circulation research 2002
Igor Feoktistov Anna E Goldstein Sergey Ryzhov Dewan Zeng Luiz Belardinelli Tatyana Voyno-Yasenetskaya Italo Biaggioni

Adenosine has been reported to stimulate or inhibit the release of angiogenic factors depending on the cell type examined. To test the hypothesis that differential expression of adenosine receptor subtypes contributes to endothelial cell heterogeneity, we studied microvascular (HMEC-1) and umbilical vein (HUVEC) human endothelial cells. Based on mRNA level and stimulation of adenylate cyclase, ...

Journal: :Neuron 2009
Manuela Schmidt Adrienne E. Dubin Matt J. Petrus Taryn J. Earley Ardem Patapoutian

Transient receptor potential A1 (TRPA1) ion channel senses a variety of noxious stimuli and is involved in nociception. Many TRPA1 agonists covalently modify the channel, which can lead to desensitization. The fate of modified TRPA1 and the mechanism of preserving its response to subsequent stimuli are not understood. Moreover, inflammatory signals sensitize TRPA1 by involving protein kinase A ...

Journal: :Blood 1996
Y Kohno X Ji S D Mawhorter M Koshiba K A Jacobson

Adenosine (ADO) is a potent bronchoconstrictor in allergic patients and has been shown to increase the release of histamine from human lung tissues. Antagonists of ADO A1 and A2A receptors are not effective in attenuating these effects. Therefore, involvement of ADO A3 receptors in the bronchoconstrictor and/or inflammatory effects have to be considered. Eosinophils also play a pivotal role in ...

Journal: :Journal of the American Society of Nephrology : JASN 2003
Francesca Di Sole Robert Cerull Soeren Petzke Valeria Casavola Gerhard Burckhardt Corinna Helmle-Kolb

Regulation of renal apical Na+/H+ exchanger 3 (NHE3) activity by adenosine has been suggested to contribute to acute control of mammalian Na(+) homeostasis. The mechanism by which adenosine controls NHE3 activity in a renal cell line was examined. The adenosine analog, N(6)-cyclopentyladenosine (CPA) exerts a bimodal effect on NHE3: CPA concentrations >10(-8) M inactivate NHE3, whereas concentr...

2014
Mònica Morales Enrique J Arenas Jelena Urosevic Marc Guiu Esther Fernández Evarist Planet Robert Bryn Fenwick Sonia Fernández-Ruiz Xavier Salvatella David Reverter Arkaitz Carracedo Joan Massagué Roger R Gomis

In estrogen receptor-negative breast cancer patients, metastatic relapse usually occurs in the lung and is responsible for the fatal outcome of the disease. Thus, a better understanding of the biology of metastasis is needed. In particular, biomarkers to identify patients that are at risk of lung metastasis could open the avenue for new therapeutic opportunities. Here we characterize the biolog...

Journal: :The Journal of clinical investigation 2005
Walter J Lukiw Jian-Guo Cui Victor L Marcheselli Merete Bodker Anja Botkjaer Katherine Gotlinger Charles N Serhan Nicolas G Bazan

Deficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline. Here we report that, in cytokine-stressed human neural cells, DHA attenuates amyloid-beta (Abeta) secretion, an effect accompanied by the formation of NPD1, a novel, DHA-derived 10,17S-docosatriene. DHA and NPD1 were reduced in Alzheimer disease (AD) hippocampal cornu ammonis re...

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