conjugation of methotrexate (mtx) (mw 454) with different molecular weights of polyethylene glycol (peg) including methoxy-peg (mpeg) 750 d and 5000 d and diol-peg 35000 d led to compounds that are physicochemically highly different from the parent compound, mtx. in this study, an hplc system consisting of c8 column and uv detector (?=342 nm), using a mixture of 30:70 v/v phosphate-citrate buff...

A reusable sensor based on a phosphonate-substituted Ru( ii ) complex allows for selective detection as low 10 −13 M of Cu 2+ ions in aqueous solutions.

The synthesis of 5' - deoxynucleoside 5' - phosphonates which contains a 5' - CP bond in place of the 5' -COP bond of the naturally occuring nucleotides is described. The preparation of phosphonate derivatives of acyclo - nucleosides and a simple method for the conversion of 1-? -D-ribofuranosyl pyrimidines to the corresponding 1-? -D-arabinofuranosyl pyrimidines are also explained

The structural features of chloromethyl ethers are shown to have a significant effect on the formation of N(7)- or N(9)- alkylated isomers of purine acyclo-nucleosides. The chemical synthesis of 2-[9-(ethoxymethyl) adenyl] phosphonate is described. This compound is active against herpesviruses.

Three octanuclear phosphonate clusters, formulated as [Ln8(O3P(t)Bu)6(μ3-OH)2(H2O)2(HO(i)Bu)(O2C(t)Bu)12](NH3(i)Pr)2 (Ln = Gd, Dy and Tb), were synthesised by refluxing a mixture of pivalic acid (HO2C(t)Bu), Ln(NO3)3·6H2O, tert-Butyl phosphonic acid (H2O3P(t)Bu) and isopropylamine ((i)PrNH2) in isobutyl alcohol (i)BuOH.

Two new metal phosphite-oxalates, CN3H6·Co(H2PO3)(C2O4) (1) and (CN3H6)2·Mn2.5(HPO3)(C2O4)2.5(H2O)·H2O (2), have been prepared under solvent-free conditions. The two open-framework compounds have diamondoid and pillared-layered structures, respectively. Their photoluminescence and magnetic properties were also investigated.

Non-halogenated “all-in-one” flame retardant HDPE.

A phosphonate pendant-armed cross-bridged cyclam chelator has been synthesized, complexed to Cu(ii), radiolabeled with (64)Cu under mild conditions, and its biodistribution studied.

Covalent attachment, through a phosphonate anchor, of hydrophilic pegylated dendrons on iron oxide nanoparticles results in versatile, robust, and highly relaxing MRI contrast agents.