Despite its more than 100-year history in experimental and clinical use, photodynamic therapy (PDT) is only starting to be appreciated for its full potential. PDT combines a photosensitizer (PS) and light in the presence of oxygen to treat cancer and other disorders. This manuscript reviews molecular mechanisms that have been evaluated over the past years for the effects of PDT at the cellular ...

Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human ...

OBJECTIVES To report outcomes of photodynamic therapy (PDT) and combined therapy with PDT and intravitreal bevacizumab (IVB) in patients with polypoidal choroidal vasculopathy (PCV). MATERIALS AND METHODS Thirty-four eyes of 31 patients with subfoveal PCV were evaluated. Nine eyes were treated with PDT and 25 eyes treated with combined therapy of PDT and IVB. All eyes had a follow-up period o...

Abstract Background Photodynamic therapy (PDT) is a clinically implemented modality to combat malignant tumor, while its efficacy largely limited by several resistance factors from tumor microenvironment (TME), such as hypoxia, anti-oxidant systems, and ATP-dependent adaptive resistances. The aim of this work construct multifunctional nanoplatform remodel multiple resistant TME for enhanced PDT...

Abstract Photodynamic therapy (PDT) has lately been identified as a promising anticancer method and gained tremendous interest due to its controllability, non-invasive nature, negligible side effects. Nevertheless, the development of PDT is hampered by two factors. One insufficient tissue penetration phototherapy laser, resulting in restricted treatment sites. Another one substantial dependence...

A targeted photosensitizer used in photodynamic therapy (PDT) was fabricated by incorporation of zinc phthalocyanine (ZnPc) and folic acid (FA) into polyvinylpyrrolidone (PVP) micelles, which exhibits excellent anticancer performance revealed by both in vitro studies and in vivo tests.

introduction: oral premalignant lesions are conditions having high potential tendency for transformation into malignancy. the use of a conservative and effective treatment modality is one of the best strategies for cancer prevention. photodynamic therapy (pdt) is a non-invasive method for topical and selective treatment of oral precancerous lesions. the present study was taken up to determine t...

The purpose of these safety guidelines is to list the requirements and conditions that need to be strictly adhered to, in order to promote and ensure the safety of patients, doctors and medical personnel during a photodynamic therapy (PDT) procedure for dermatological, cutaneous lesions. In the field of dermatology, the most common type of PDT procedure is such where a topical photosensitizer, ...

Case report: In this case study we report the treatment outcome of using photodynamic diagnosis (PDD) and chlorine e6 based PDT as part of adjuvant therapy in a patient with locally advanced nasal carcinoma. The patient had previously refused surgical ablation of the nose for cosmetic and psychological reasons. Chlorin E6 was given IV at a dose of 1 mg/sqm BSA three hours before PDT procedure. ...