Recent experimental studies in Japan on the evaluation of potential health hazards from phthalate esters used in manufacturing poly (vinyl chloride) as well as several plastics for medical devices and for food containers and packages were introduced. Development of pulmonary granuloma formation after intravenous injection of diethylhexyl phthalate was assumed to be dependent on the particle siz...

Diethyl phthalate works as a phthalate plasticizer and is ubiquitously used in personal care products, cosmetics, medical equipment and pharmaceutical coating. Diethyl phthalate is considered a potential endocrine disruptor. Previously we found diethyl phthalate enhanced apoptosis induced by serum deprivation in PC12 cells. However, the relationship between diethyl phthalate and longevity relat...

PURPOSE OF REVIEW Phthalates are multifunctional chemicals used in personal care products, medications, and plastics. We reviewed the epidemiological literature examining the relationship between early life phthalate exposure and pediatric health outcomes. RECENT FINDINGS Five studies from Asia, Europe, and the United States suggest that childhood exposure to di-2-ethylhexyl phthalate (DEHP) ...

Phthalate has been used worldwide in various products for years. Little is known about the association between phthalate exposure and biomarkers of oxidative stress in adolescents and young adults. Among 886 subjects recruited from a population-based cohort during 2006 to 2008, 751 subjects (12-30 years) with complete phthalate metabolites and oxidation stress measurement were enrolled in this ...

A new clip-like receptor, which comprises two thiourea-based binding groups and two naphthalene units, has been designed and synthesized as a fluorescent chemosensor for distinguishing o-phthalate from two other isomers of dicarboxylates. Upon the addition of these three ions, the emission intensity at 420 nm (excitation at 340 nm) decreases drastically through PET. When excited at 380 nm, a ne...

With the recent demonstration of the migration of phthalate ester plasticizers from vinyl plastic biomedical devices (1-4), its identification in human and animal tissues (5, 6), and evidence for its ubiquitous distribution in the environment (7, 8),tt it has become necessary to reevaluate the toxicologic potential of this class of chemical compounds. Di-2-ethylhexyl phthalate (DEHP), as an exa...

Dibutyl phthalate (DBP) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. DBP is found in almost every plastic material and is believed to be persistent in the environment. Various analytical methods have been used to measure DBP in different matrices. Considering the ubiquitous nature of DBP, the most important challenge in DBP analyses is the contam...

BACKGROUND The purpose of this study was to examine the relationship of phthalates exposure with thyroid function in pregnant women and their newborns. METHODS One hundred and forty-eight Taiwanese maternal and infant pairs were recruited from E-Da hospital in southern Taiwan between 2009 and 2010 for analysis. One-spot urine samples and blood samples in the third trimester of pregnant women ...

Di(2-ethylhexyl) phthalate (DEHP) produced seminiferous tubular atrophy and reductions in seminal vesicle and prostate weight in 4-week-old, but not in 15-week-old rats. Di-n-pentyl phthalate (DPP) did produce atrophy in the older rats but this developed more slowly than in young animals. Coadministration of testosterone or gonadotrophins did not protect against phthalate-induced testicular tox...

The International Agency for Research on Cancer classified the di-2-ethylhexyl phthalate (DEHP) as "possibly carcinogenic to humans". In vitro studies reported that phthalate exposure resulted in induction of several nuclear transcription factors that are activators of telomerase reverse transcriptase (TERT) and telomerase activity of the human telomerase complex. The objective of this study wa...