Tolerance and physical dependence caused by chronic treatment of narcotics are good models to study basic neuronal plasticity. Activation of the NMDA subtype of the glutamate receptor has been implicated as an anti-opioid system in the development of morphine analgesic tolerance and dependence. The present study examines the specific role of the epsilon1 subunit of the NMDA receptor using mice ...

BACKGROUND Previous research has documented a relationship between child sexual abuse and alcohol dependence. This paper extends that work by providing a comprehensive description of past year and lifetime alcohol consumption patterns, consequences, and dependence among women reporting either physical and sexual abuse in a national sample. METHODS This study used survey data from 3,680 women ...

BACKGROUND Scant research has examined the determinants of primary exercise dependence symptoms in youth. Study purposes were to examine sex differences across leisure-time exercise behavior, motivation, and primary exercise dependence symptoms in youth and the extent to which exercise behavior and motivation predicted exercise dependence within the Self-Determination Theory framework. METHOD...

The mammalian hippocampal formation appears to play a major role in the generation of internal representations of spatial relationships. In rats, this role is reflected in the spatially selective discharge of hippocampal pyramidal cells. The principal metric for coding spatial relationships might be the organism's own movements in space, that is, the spatial relationship between two locations i...

PURPOSE Opportunities for social interaction are lacking within today's nursing homes and staff frequently communicate messages of dependence, incompetence, and control to residents. This study evaluated a brief educational program designed to increase staff awareness of intergenerational speech modifications such as elderspeak and strategies to enhance communication. DESIGN AND METHODS A com...

Relational data are often represented as a square matrix, the entries of which record the relationships between pairs of objects. Many statistical methods for the analysis of such data assume some degree of similarity or dependence between objects in terms of the way they relate to each other. However, formal tests for such dependence have not been developed. We provide a test for such dependen...

We report four experiments that investigated the representation of novel three-dimensional (3D) objects by the human visual system. In the first experiment, canonical views were demonstrated for novel objects seen equally often from all test viewpoints. The next two experiments showed that the canonical views persisted under repeated testing, and in the presence of a variety of depth cues, incl...

We present the group of the Wulff plot, which describes the orientation dependence of physical properties of interfaces, such as grain boundaries, between two crystals of arbitrary spatial relationship. From the group of the Wulff plot, symmetry constraints upon the forms of crystals grown in crystalline enviroments are derived. Examples of other applications are given.

The emotional well-being of persons with dementia is an aspect of their quality of life. We examined the stability of informant-rated and self-reported emotion, and the influence of mental status and physical dependence on ratings; we modeled concordance between ratings at both the within- and between-person levels of analysis. We used multilevel modeling to examine data collected over 12 days ...

We report on the penetration of cylindrical projectiles dropped from rest into a dry, noncohesive granular medium. The cylinder length, diameter, density, and tip shape are all explicitly varied. For deep penetrations, as compared to the cylinder diameter, the data collapse onto a single scaling law that varies as the 1/3 power of the total drop distance, the 1/2 power of cylinder length, and t...