نتایج جستجو برای: physician clinician npc

تعداد نتایج: 78078  

2015
Qiu-Yan He Hong-Mei Yi Hong Yi Ta Xiao Jia-Quan Qu Li Yuan Jin-Feng Zhu Jiao-Yang Li Yuan-Yuan Wang Li-Na Li Juan Feng Shan-Shan Lu Zhi-Qiang Xiao

The role and underlying mechanism of Raf kinase inhibitory protein (RKIP) in nasopharyngeal carcinoma (NPC) metastasis remain unclear. Here, we showed that RKIP was downregulated in the NPC with high metastatic potentials, and its decrement correlated with NPC metastasis and poor patient survival, and was an independent predictor for reduced overall survival. With a combination of loss-of-funct...

2017
Jian-Gang Wang Wu-Ping Tang Ming-Chu Liao Yan-Ping Liu Xiao-Hong Ai

BACKGROUND Recent studies reported that miRNAs play important roles in the carcinogenesis and progression of nasopharyngeal carcinoma (NPC). Therefore, further studies are warranted to better elucidate the function and mechanism of miRNAs in NPC. METHODS Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the miR-99a expression in NPC cell lines and tissue...

Journal: :Current Biology 2004
Colin P.C. De Souza Aysha H. Osmani Shahr B. Hashmi Stephen A. Osmani

BACKGROUND Many organisms undergo closed mitosis and locate tubulin and mitotic kinases to nuclei only during mitosis. How this is regulated is unknown. Interestingly, the NIMA kinase of Aspergillus nidulans interacts with two nuclear pore complex (NPC) proteins and NIMA is required for mitotic localization of the Cdk1 kinase to nuclei. Therefore, we wished to define the mechanism by which the ...

2017
Qian Cui Fu-Tuo Feng Miao Xu Wen-Sheng Liu You-Yuan Yao Shang-Hang Xie Xi-Zhao Li Zu-Lu Ye Qi-Sheng Feng Li-Zhen Chen Jin-Xin Bei Lin Feng Qi-Hong Huang Wei-Hua Jia Su-Mei Cao Ellen T. Chang Weimin Ye Hans-Olov Adami Yi-Xin Zeng

Genetic susceptibility and Epstein-Barr virus (EBV) infection are important etiological factors in nasopharyngeal carcinoma (NPC). In this study, in southern China, where NPC is endemic, a single nucleotide polymorphism (SNP) in the EBV-encoded RPMS1 gene (locus 155391: G > A [G155391A]) and seven host SNPs (rs1412829, rs28421666, rs2860580, rs2894207, rs31489, rs6774494, and rs9510787) were co...

2016
Tian-Hao Liu Fang Zheng Mu-Yan Cai Lin Guo Huan-Xin Lin Jie-Wei Chen Yi-Ji Liao Hsiang-Fu Kung Yi-Xin Zeng Dan Xie

Nasopharyngeal carcinoma (NPC) is one of the most prevalent forms of highly invasive malignancy in Southern China and Southeast Asia. The pathogenesis of NPC is a multistep process driven by the acquisition of numerous genetic abnormalities. We investigated the potential oncogenic role of the Rho-guanine nucleotide exchange factor 3 gene, ARHGEF3, in NPC pathogenesis. Expression levels of ARHGE...

2017
Eun-Ah Sung Kyung-Rok Yu Ji-Hee Shin Yoojin Seo Hyung-Sik Kim Myung Guen Koog Insung Kang Jae-Jun Kim Byung-Chul Lee Tae-Hoon Shin Jin Young Lee Seunghee Lee Tae-Wook Kang Soon Won Choi Kyung-Sun Kang

Niemann-Pick disease type C (NPC) is a neurodegenerative and lysosomal lipid storage disorder, characterized by the abnormal accumulation of unesterified cholesterol and glycolipids, which is caused by mutations in the NPC1 genes. Here, we report the generation of human induced neural stem cells from NPC patient-derived fibroblasts (NPC-iNSCs) using only two reprogramming factors SOX2 and HMGA2...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Thian Sze Wong Dora Lai-Wen Kwong Jonathan Shun-Tong Sham Sai Wah Tsao William Ignace Wei Yok Lam Kwong Anthony Po-Wing Yuen

PURPOSE The methylation of high-in-normal-1 (HIN-1) gene promoter in undifferentiated nasopharyngeal carcinoma (NPC) is studied. EXPERIMENTAL DESIGN The methylation status of HIN-1 in NPC cell lines, primary NPC, paired nasopharyngeal swabs, paired throat-rinsing fluid, and paired peripheral blood was assessed by methylation-specific PCR assay. The relationship between HIN-1 promoter methylat...

Journal: :Patient education and counseling 2012
Ashley M Hesson Issidoros Sarinopoulos Richard M Frankel Robert C Smith

OBJECTIVES To evaluate interactional effects of patient-centered interviewing (PCI) compared to isolated clinician-centered interviewing (CCI). METHODS We conducted a pilot study comparing PCI (N=4) to CCI (N=4) for simulated new-patient visits. We rated interviews independently and measured patient satisfaction with the interaction via a validated questionnaire. We conducted interactional so...

Journal: :Journal of medical ethics 2004
N D Berkman M K Wynia L R Churchill

BACKGROUND Patients today interact with physicians, physician groups, and health plans, each of which may follow distinct ethical guidelines. METHOD We systematically compared physician codes of ethics with ethics policies at physician group practices and health plans, using the 1998-99 policies of 38 organisations-18 medical associations (associations), nine physician group practices (groups...

2016
Wei Hu Lushan Xiao Chuanhui Cao Shengni Hua Dehua Wu

Increasing evidence has shown that UBE2T plays an important role in genomic integrity and carcinogenesis; however, its role in nasopharyngeal carcinoma (NPC) has not been investigated. Here, we evaluated the clinicopathological significance of UBE2T in NPC and its underlying mechanisms. Using immunohistochemical analysis of UBE2T expression in NPC samples, we demonstrated that UBE2T is highly e...

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