Protein unfolding occurs at both low and high temperatures, although in most cases, only the high-temperature transition can be experimentally studied. A pressing question is how much the low- and high-temperature denatured states, although thermodynamically equivalent, are structurally and kinetically similar. We have combined experimental and computational approaches to compare the high- and ...

Central nervous system (CNS) barriers predominantly mediate the immune-privileged status of the brain, and are also important regulators of neuroimmune communication. It is increasingly appreciated that communication between the brain and immune system contributes to physiologic processes, adaptive responses, and disease states. In this review, we discuss the highly specialized features of brai...

PURPOSE/OBJECTIVES To describe the experience of chemotherapy-induced premature menopause (CIPM) among Latinas, explore how CIPM was assimilated into the breast cancer experience, and relate measured acculturation levels to the CIPM experience. RESEARCH APPROACH Interpretive descriptive method from a feminist inquiry lens. SETTING Telephone interviews with participants from 12 states in the...

Volume 71, Number 8 www.aafp.org/afp American Family Physician 1563 S ince the first permanent pacemaker was implanted in 1958, device therapy has continued to grow. It is estimated that more than 300,000 patients in the United States receive a permanent pacemaker each year, and about 900,000 pacemakers are implanted worldwide. The indications for pacemaker therapy have expanded in the past 45 ...

OBJECTIVE To explain the energetic physiologic basis for acupuncture electroconductance effects and for gas discharge visualization (GDV) assessment methods, using a quantum biophysical model of entropy and information flows. DESCRIPTION The main reservoir of free energy in biologic processes is electron-excited states of complex molecular systems. Communities of delocalized excited pi-electr...

This guideline updates and replaces the 4th edition of the AAGBI Standards of Monitoring published in 2007. The aim of this document is to provide guidance on the minimum standards for physiological monitoring of any patient undergoing anaesthesia or sedation under the care of an anaesthetist. The recommendations are primarily aimed at anaesthetists practising in the United Kingdom and Ireland....

in our previous studies we have evaluated the role of antioxidants and trace elements in potentially malignant disorders and cancers of the oral cavity, taking into consideration the importance of antioxidants as biomarkers in cancer detection. we felt that other than evaluation, the correlation and interdependence that existed among antioxidants and trace elements require further evaluation in...

Crystallographic and electron microscopy studies revealed genuflexed (bent) integrins in both unliganded (inactive) and physiologic ligand-bound (active) states, suggesting that local conformational changes are sufficient for activation. Herein we have explored the role of local changes in the contact region between the membrane-proximal β−tail domain (βTD) and the ligand-binding βA domain of t...

BACKGROUND Nociceptive pain is a major problem in clinical neurology. Peripheral nerve injury may change the physiology of the dorsal horn so that pain becomes progressively centralized. OBJECTIVE To review mechanisms underlying the plasticity of dorsal root ganglia and dorsal horn neurons that lead to central pain from a peripheral nerve injury. RESULTS Evidence is reviewed that points to ...

Physiology in microgravity is a challenging field of research because of limited resources. Though humans have been in space for 50 years most meaningful data has been collected only within the last 15 years. While expensive studies with small sample sizes make obtaining and interpreting data difficult, some general conclusions about the human physiological response to microgravity can be drawn...