Vascular luminal castings of rabbit eyes were microdissected and studied with scanning electron microscopy to elucidate the three-dimensional angioarchitecture of the optic nerve head. Using sequential microdissection, an incomplete arterial circle was identified as terminal branches of two to three short posterior ciliary arteries around the optic nerve head. Several recurrent branches from th...

2003;43:96-98), Doepp et al reported that 68% of patients with migraine experienced increased headache intensity when a Queckenstedt maneuver was performed with the patients supine. They concluded thdt the increased headache intensity was caused by in-tracranial venous distension. This conclusion may be incorrect. Schumacher and Wolff reported that by increasing intracranial pressure and thereb...

We tested the hypothesis that blood flow through cerebral collateral vessels is lower in stroke-prone spontaneously hypertensive rats (SHRSP) than in normotensive Wistar-Kyoto rats (WKY) after occlusion of the middle cerebral artery and during maximal vasodilatation. Cerebral blood flow, measured with microspheres, was similar in adult male SHRSP and WKY under control conditions. In both strain...

The cerebral cortex microvascular system of normal (unaltered) brains is described and compared with that of altered ones by perinatal brain damage. The brain’ microvascular system evolves from the pial capillary plexus an important meningeal compartment poorly studied. A pial capillary anastomotic plexus already cover the cortex in 6-week-old embryos, although its vascularization will not star...

BACKGROUND AND OBJECTIVE The objective of this article is to quantify the effect of hyper-osmotic agent (glycerol) on blood velocity in hamster skin blood vessels measured with a dynamic imaging technique, laser speckle contrast imaging (LSCI). STUDY DESIGN/MATERIALS AND METHODS In this study a dorsal skin-flap window was implanted on the hamster skin. The hyper-osmotic drug, that is, glycero...

The newborn pig is a widely accepted large animal model of hypoxic/ischemic (H/I) encephalopathy (HIE) of the term neonate appropriate for translational research. The methodology of the induction of H/I stress shows extensive variability of the literature, and little is known how these affect study outcome. The purpose of the present study was to determine the cerebrocortical microvascular effe...

Acute occlusion of a middle cerebral artery (MCA) reduces cerebral blood flow in normotensive Wistar-Kyoto rats (WKY) and in stroke-prone spontaneously hypertensive rats (SHRSP). The goal of this study was to determine whether MCA occlusion produces a sustained reduction in cerebral blood flow or whether collateral vessels restore blood flow to normal levels. We measured blood flow through cere...