We revisited a classic study of morphological variation in the oldfield mouse (Peromyscus polionotus) to estimate the strength of selection acting on pigmentation patterns and to identify the underlying genes. We measured 215 specimens collected by Francis Sumner in the 1920s from eight populations across a 155-km, environmentally variable transect from the white sands of Florida's Gulf coast t...

Introduction: Macular amyloidosis is a relatively rare disease. A basic change appears to be amyloid material deposition in an apparently normal skin. The characteristic features of the disease are reticulate and ripple brown pigmentation in interscapular regions. Shoulder, back and chest. There are several reports indicating the association of the disease with rubbing against the skin. Accordi...

Introduction It has been said that pigmentation of the skin is the most distinctive feature of Addison's disease (British Medical Journal, 1963) and that no other clinical feature is as useful diagnostically (Dunlop, 1963). Four cases are presented where no pigmentation was found. The difficulties in diagnosis are discussed and it is suggested that Addison's disease without pigmentation is comm...