Objectives: The purpose of the study was to assess the relationship between selective serotonin reuptake inhibitors use and hepatocellular carcinoma in Taiwan. Methods: Using the database of the Taiwan National Health Insurance Program, we conducted a case-control study to identify 4901 subjects aged 20 years and more with newly diagnosed hepatocellular carcinoma in 2000-2013 as the cases. We r...

Hypochondriasis is a condition characterized by an unrealistic fear of having serious medical illness resulting in health anxiety. Currently, no evidence-based pharmacological treatment options are available for the hypochondriasis. Since selective serotonin reuptake inhibitors (SSRIs) first-line option anxiety disorders, they may be useful relieving hypochondriasis symptoms. Moreover, off-labe...

Binge Eating Disorder (BED) is a common atypical eating disorder. The treatment of BED calls for multi-professional expertise and co-operation between doctors, psychologists and nutritional therapists. Different therapeutic and psychosocial approaches are the primary means in treating BED. Medication may be used as supportive treatment. Selective serotonin reuptake inhibitors (SSRIs) are the mo...

BACKGROUND Migraine, ranked as the 7th-highest specific cause of disability worldwide, has caused an enormous burden on the economy and society. Tricyclic antidepressant (TCA) is one of the most commonly drugs for migraine prevention. However, evidence about the efficacy and tolerability of TCAs in the prophylaxis of migraine in adults is somewhat confusing. METHODS A computerized literature ...

INTRODUCTION It has clearly been demonstrated that depressive disorders constitute a major worldwide public health problem, with massive economic and quality-of-life consequences. Existing pharmacological treatments have limited efficacy, with only about a third of patients achieving remission on any one medication. Delayed onset of action and variable tolerability contribute to this limited ef...

New data on the pharmacology of tricyclic antidepressants (TCAs), their affinities for human cloned CNS receptors and their cytochrome P450 enzyme inhibition profiles, allow improved deductions concerning their effects and interactions and indicate which of the TCAs are the most useful. The relative toxicity of TCAs continues to be more precisely defined, as do TCA interactions with selective s...

This paper examines the controversy over the use of selective serotonin-reuptake inhibitors (SSRIs) in the treatment of children and adolescents. Arguments for and against the use of SSRIs with pediatric populations are evaluated. Supporting SSRI treatment are findings that SSRIs are effective, the potential accessibility of medication, and findings that SSRIs have played a role in the overall ...

QUESTION Functional gastrointestinal disorders (FGIDs) are complex conditions I see in some of my pediatric patients. The indications for antidepressants such as selective serotonin reuptake inhibitors (SSRIs) do not include treatment of FGIDs; however, some children are prescribed SSRIs for this condition. Are antidepressants effective and safe to use for treating FGIDs in children and adolesc...

Depression during pregnancy occurs frequently and selective serotonin reuptake inhibitors (SSRIs) are often the drug of choice when treating pregnant women. Most published studies found no increased risks of congenital malformations in association with SSRIs, but there are reports of various malformations for SSRIs as a group and for specific SSRIs. To assess potential adverse effects of SSRIs ...