Bone marrow transplantation (BMT) is indicated for selected genetic and hematologic diseases and for hematopoietic reconstitution in cases of iatrogenic or accidental ablation of BM.’-5 Additionally, allogeneic BMT may contribute to the therapy of leukemia through graft-versus-leukemia effects (GVL), which are associated with, but possibly independent of, chronic graft-versus-host disease (GVHD...

Embryonic hematopoiesis starts via the generation of primitive red blood cells (RBCs) that satisfy the embryo’s immediate oxygen needs. Although primitive RBCs were thought to retain their nuclei, recent studies have shown that primitive RBCs in mice enucleate in the fetal liver. It has been unknown whether human primitive RBCs enucleate, and what hematopoietic site might support this process. ...

background: cryptorchidism is a common malformation in neonates; surgery or medical treatments are applied during childhood. untreated cryptorchid testes are in the risk of intratubular germ cell neoplasia (igcn) and consequently invasive testicular tumors which could be shown by immunohistochemistry staining for placental like acid phosphatase (plap) marker. objective: we designed this study t...

background: cesarean section delivery can lead to much maternal morbidity. different cytokines have been reported to be influenced by the mode of delivery. objective: to investigate the influence of mode of delivery on maternal, placental and cord sera of interferon gamma (ifn-γ), interleukin-4 (il-4) and interleukin-10 (il-10) levels. methods: these three cytokines were measured using elisa in...

In pregnancy, the decidual cells produce and secrete large amounts of macrophage colony-stimulating factor (M-CSF). M-CSF stimulates the proliferation and differentiation of trophoblasts. In addition, it stimulates them in a dose-dependent manner to produce certain hormones, such as human chorionic gonadotropin and human placental lactogen. Based on these facts, M-CSF is considered to be an ...

OBJECTIVE This study addressed the hypothesis that placental endothelial lipase (EL) expression is affected by pregnancies complicated by obesity and gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS EL expression in placental tissues from pregnancies complicated by obesity, GDM, or obesity combined with GDM (obese-GDM) was analyzed by quantitative RT-PCR. Moreover, primary pla...

Although it is clear that human chorionic gonadotropin (hCG) and progesterone play fundamental roles in pregnancy, the regulation of placental production of these hormones remains to be defined. Recent evidence suggests that the human placenta expresses proteins related to inhibin (alpha beta subunits) or activin (beta beta subunits). Inhibin and activin (follicle-stimulating hormone-releasing ...

BACKGROUND Maternal immunity is thought to play a major role in the increased susceptibility of pregnant women to Plasmodium falciparum malaria. Few studies exist on immunohistochemical characterization of the placental inflammatory infiltrate. The current study was conducted in Gadarif hospital in an area characterized by unstable malaria transmission in eastern Sudan. METHOD Ninety three pl...

A defining feature of mammals is the development in utero of the fetus supported by the constant flow of nutrients from the mother obtained via a specialized organ: the placenta. The placenta is also a major endocrine organ that synthesizes vast quantities of hormones and cytokines to instruct both maternal and fetal physiology. Nearly 20 years ago, David Haig and colleagues proposed that place...