Placental site trophoblastic tumor is a very rare variant of gestational trophoblastic disease which differs histologically and immunocytochemically from gestational choriocarcinoma. The English language literature includes only 74 reported cases. Seventeen patients have been managed at Charing Cross Hospital with this diagnosis. The median follow-up is 4.6 years, and the 5-year overall surviva...

Placental site trophoblastic tumor (PSTT) is a highly rare form of gestational trophoblastic diseases that arise from intermediate trophoblastic cells. By presenting this case, we aimed to review the treatment and diagnosis, approach to PSTT. A 31-year-old (G2P1A1L1) patient had abnormal vaginal bleeding. Serum ß-HCG was 5.82 mIU/ml and the transvaginal USG detected a polypoid mass in uterine c...

Gestational trophoblastic disease (GTD) is a group of several rare tumours that arise in the uterus from placental cells during pregnancy. These are benign majority cases but may be malignant. A 38-year-old woman, Gravida 4 Para 1 A3, was admitted at term 19 weeks amenorrhea +6Days for Fetal death utero (FDIU). evacuation induced medically by misoprostol. The ultrasound showed persistent thicke...

BACKGROUND Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that functions in embryonic cell growth and differentiation and is highly expressed in the placenta. GPC3 is mutated in Simpson-Golabi-Behmel syndrome, which is characterized by tissue overgrowth and an increased risk of embryonal malignancies. GPC3 has also been implicated in sporadic cancer, particularly hepatocellu...

The objective of this study was to evaluate correlated responses in conceptus development and traits physiologically relevant for placental function in swine from a selection experiment that resulted in differences in placental weight (PW) and efficiency (PE = birthweight/placental weight). Generation 3, second parity females from 2 lines with a history of selection on an index predicting eithe...

Epithelioid trophoblastic tumor (ETT) is a very rare variant of gestational trophoblastic disease (GTD) which arises in reproductive age women with prior gestational history. Although abnormal vaginal bleeding is the most common symptom of ETT, there are no reported pathognomonic symptoms of ETT because of its rarity. ETT is similar to placental site trophoblastic tumor in terms of its slow gro...