Th e aim of the present study was to evaluate the eff ect of ovine placenta extract, obtained by affi nity chromatography on immobilized wheat germ lectin, on mammogenesis, lactogenesis, and galactopoiesis in pregnant and lactating sheep. Placental extract (100 μg/mL protein concentration) was subcutaneously injected to pregnant sheep in days 1, 4, 7, 10, and 13 of the experiment (totally 10 mL...

Human GCMa transcription factor regulates expression of syncytin, a placental fusogenic protein mediating trophoblastic fusion. Recently, we have demonstrated that CBP-mediated GCMa acetylation underlies the activated cAMP/PKA signaling pathway that stimulates trophoblastic fusion. Because protein acetylation is a reversible modification governed by histone acetyltransferases (HATs) and histone...

Introduction: Placental teratoma is an uncommon, non-trophoblastic benign tumor. Since the first description of this type tumor by Morvilli in 1925, only a few cases abnormality have been diagnosed and reported. Case presentation: We describe here 35-year-old pregnant woman admitted for elective cesarean section. The placenta membranes were delivered spontaneously. After delivering placenta, ma...

AIMS To study the localisation of the endothelial nitric oxide synthase (eNOS) in the normal placenta, with special emphasis on the implantation site in the first trimester of pregnancy, and in the different subtypes of trophoblastic cells in gestational trophoblastic disease. METHODS The immunoperoxidase technique with an antibody directed against eNOS was applied to paraffin sections from f...

Chorangiocarcinoma is an extremely rare primary placental neoplasm, with only five cases reported in the literature (Table 1). Some researchers considered it as a bona fide chorangiocarcinoma, but most cases described a chorangioma with abnormal trophoblastic proliferation. In spite of atypia in cytology, marked mitosis and tumor necrosis, chorangiocarcinoma was always reported benign. No metas...