It is estimated that EU re-registration will result in approximately 65% of 1st ,2nd and 3rd list active ingredients being removed from the market. It is more difficult to estimate how many uses will remain on product labels following member state re-registration. Up to 60 or 70 % of target species and crops could be lost, if use patterns which fall outside the representative GAP (one safe use ...

The use of pesticides is sometimes considered to have dated from the latter half of the 19th century. However, a survey of the classical literature (Smith and Secoy, 1975) has shown that there were frequent references to chemicals and natural products which appear to have been used for the control of plant disease and for killing unwanted plants and animals. As a result of further research into...

The rationalisation of the new multidrug and multitarget concept of therapy in classical medicine will have also great implication on the future basic research in phytomedicine and an evidence based phytotherapy. It requires a concerted cooperation between phytochemists, molecular biologists, pharmacologists and clinicians with the aim to use modern high-tech methods for the standardisation of ...

Utilization of natural products is radically changing. Changes were mainly due to the outcome in the market of a plethora of new food supplements, and in particular those generally named botanicals for their common plant origin. The validation of these novel products needs powerful analytical devices tailored for the study of herbal extracts in order to assess composition and face their natural...

HIV replication assays are important tools for HIV drug discovery efforts. Here, we present a full HIV replication system (EASY-HIT) for the identification and analysis of HIV inhibitors. This technology is based on adherently growing HIV-susceptible cells, with a stable fluorescent reporter gene activated by HIV Tat and Rev. A fluorescence-based assay was designed that measures HIV infection b...

Liver disease, also known as hepatic disease is any condition that may cause disturbance of liver function and causes illness. The liver is responsible for many vital functions within the body and should it become diseased or injured, the loss of those functions can cause significant damage to the body. Natural products which are derived from plant extracts, herbs, animals, marine and microbes ...

Many essential oils are extracted, analysed and their main components are identified, characterised and then published without any biological testing whatsoever. Their useful biological activities can remain unknown for years. Yet, the search for these activities often increases our knowledge of the potential use of oils in therapeutics. Therefore, there is a real need for a simple, reliable an...

Over the last several decades, the number of pharmacologically active natural products has significantly increased and several natural product families have taken shape. This review highlights the family of tetronate and spirotetronate compounds, which show a vast structural and functional diversity. The rapid growth of this group has created the need for a comprehensive overview and classifica...

Since the development of agriculture, humans have relied on the cultivation of plants to satisfy our increasing demand for food, natural products, and other raw materials. As we understand more about plant development, we can better manipulate plants to fulfill our particular needs. Auxins are a class of simple metabolites that coordinate many developmental activities like growth and the appear...

Lactococcus garvieae is an important fish pathogen and an emerging opportunistic human pathogen, as well as a component of natural microbiota in dairy and meat products. We present the first report of genome sequences of L. garvieae I113 and Tac2 strains isolated from a meat source.