BACKGROUND Successful hematopoietic stem cell transplantation (HSCT) requires a rapid and durable hematopoietic recovery. AIM The aim of our study was to analyse factors that influence hematopoietic recovery after autologous HSCT. MATERIALS AND METHODS Multiple regression analysis was used to analyse factors affecting neutrophil and platelet engraftment in 90 autologous transplanted patient...

AIMS In humans, little is known about the effects of platelet-leucocyte interactions on blood viscosity and microvascular perfusion. This study tested the hypotheses that (1) activation and interactions between platelets and leucocytes may have an impact on microvascular blood viscosity and perfusion in patients with stage II peripheral arterial occlusive disease, and (2) a powerful antiplatele...

Aspirin, which has just celebrated its 111th anniversary, remains one of the most widely used antiplatelet agents worldwide (1). Its high efficacy has made aspirin the cornerstone of treatment in patients suffering from cardiovascular diseases; indeed, daily aspirin therapy reduces the risk of stroke, myocardial infarction and death by approximately 25% (2). Early investigation into aspirin’s p...

Background: Immune thrombocytopenia is a hematologic disorder characterized by low platelet count and variable bleeding manifestations due to immune-mediated platelet destruction and/or suppression of platelet production. This study was performed to evaluate characteristics and clinical presentations of adult patients with immune thrombocytopenia and to explore the clinical value of platelet an...

BACKGROUND Heparin-induced thrombocytopenia (HIT) is a life and limb-threatening condition caused by the binding of platelet-activating antibodies (IgG) to multimolecular platelet factor 4 (PF4)/heparin complexes because of heparin exposure. The by-product of this interaction is thrombin formation which substantially increases the risk of venous and/or arterial thromboembolism. Currently, only ...

Cyclic thrombocytopenia is a rare disorder characterized by periodic decreases and increases in platelet levels. Recent data suggest these fluctuations result from periodic failure of effective platelet production or periodic immune-mediated platelet destruction.’.’ However, the pathogenesis of this disorder is uncertain. We developed an enzyme-linked immunosorbent assay (ELISA) of serum thromb...