BACKGROUND Chronic oxidative stress and inflammation severely affect the normal physiology of neurons and lead to neurodegenerative disorders such as Alzheimer's disease (AD). Polyphenols proved a boon in the prevention of dementia due to their antioxidant and neuroprotective potential. Caffeic acid phenethyl ester (CAPE) is a natural polyphenolic compound attributed with antioxidant, immunomod...

This paper is focused on affective and cognitive disorders induced by direct exposure to lead chloride (Pb) the possible implication of oxidative stress in male WISTAR rats. Using stereotaxic surgery, a group wistar rats received an intracerebral injection 3 μL (1 mg / L) into right hippocampus or 0.9% Nacl for shame operated controls groups. After 4 days rest, series benchmark neurobehavioral ...

Leptin is released by adipose tissue. can cross the blood–brain barrier and bind to receptors on neurons in brain areas exert its biological function when into circulation. This study aimed determine influences of intra-amygdalar administration high low doses leptin anxiety, depression, learning behaviors rats. In experimental protocol I, injection (0.1 1 μg/ kg) saline were administered 30 min...

Response strategy in the dual-solution plus maze is regarded as a form of stimulus-response learning. In this study, by using an outcome devaluation procedure, we show that it can be based on both action-outcome and stimulus-response habit learning, depending on the amount of training that the animals receive. Furthermore, we show that deactivation of the dorso-medial and the dorso-lateral stri...

BC1 RNA is a small non-messenger RNA common in dendritic microdomains of neurons in rodents. In order to investigate its possible role in learning and behaviour, we compared controls and knockout mice from three independent founder lines established from separate embryonic stem cells. Mutant mice were healthy with normal brain morphology and appeared to have no neurological deficits. A series o...

Prior test experience compromises the anxiolytic efficacy of benzodiazepines (BZs) either in rats or mice, a phenomenon not exclusive to the elevated plus-maze (EPM) animal model of anxiety, which is referred to as "one-trial tolerance." However, it remains to be determined whether a similar event occurs when testing other drugs that also possess binding-sites on the GABA(A) receptor, such as e...

Using an airtight Y maze and a new method to induce peripheral anosmia in ferrets, we assessed the contribution of conspecific odors, either alone or in combination with visual and auditory signals, to heterosexual partner preference. Sexually naive ferrets were gonadectomized and treated with sex steroids, after which their nares were either bilaterally occluded using dental impression materia...

Diabetes mellitus is one of the most common causes of neuropathy. Although antioxidant and antidiabetic effects of the aqueous extract of purslane (Portulaca oleracea) (AEOP) have been demonstrated before by other researchers, we did not find any study that assessed the psychobiological effects of AEOP in diabetes induced animals. Thirty ovariectomized (OVX) female Wistar rats were randomly div...

Aim of present research was to investigate in male Wistar rats whether a prior elevated plus maze experience modifies the temporal structure of the behavioral response following a retest applied after 24h. Video files were coded by means of a software coder and event log files generated for each subject were analyzed by means of a specific software for temporal pattern analysis (Theme). Present...