نتایج جستجو برای: pml

تعداد نتایج: 3358  

1998
Kathryn Nason-Burchenal Janet Allopenna Agnes Bègue Dominique Stéhelin Ethan Dmitrovsky Patrick Martin

Acute promyelocytic leukemia (APL) cells, containing the t(15;17) rearrangement, express the fusion protein, PML/ RARa. Clinically, patients respond to all-trans retinoic acid (ATRA) through complete remissions associated with myeloid maturation of leukemic cells. This clinical ATRA response of APL is linked to PML/RARa expression. Unfortunately, these remissions are transient and relapsed APL ...

2004
Andrew A. Lane Timothy J. Ley

Expression of the PML-retinoic acid receptor (PML-RAR ) fusion protein is the initiating genetic event for acute promyelocytic leukemia (APL), but the molecular mechanisms responsible for disease initiation are not yet clear. Several observations have suggested that early myeloid cells are uniquely susceptible to transformation by PML-RAR . Recently, we have shown that the early myeloid-specifi...

2010
Zdenek Hodny Sona Hubackova Jiri Bartek

morphology and other phenotypic features characteristic of cellular senescence can be triggered by telomere attrition (replicative senescence) and various stresses such as activated oncogenes or genotoxic treatments (premature senescence). Physiological relevance of cellular senescence is apparent from its emerging roles in aging, in tumor pathogenesis as an inducible barrier to tumor progressi...

2016
Dhanashri P. Miskin Long H. Ngo Igor J. Koralnik

We investigated delay in diagnosing progressive multifocal leukoencephalopathy (PML). The median time from initial symptom to diagnosis was 74 days (range 1-1643) in 111 PML patients seen at our institution from 1993 to 2015. Another diagnosis was considered before PML in nearly two-thirds, and more than three-quarters of patients suffered from diagnostic delay greater than 1 month, irrespectiv...

2001
Y. Q. Zeng J. Q. He Q. H. Liu

The perfectly matched layer (PML) was first introduced by Berenger as a material absorbing boundary condition (ABC) for electromagnetic waves. In this paper, a method is developed to extend the perfectly matched layer to simulating seismic wave propagation in poroelastic media. This nonphysical material is used at the computational edge of a finite-difference algorithm as an ABC to truncate unb...

Journal: :Science signaling 2015
Domenico Fasci Veronica Anania Jennie Lill Guy Salvesen

Arsenic trioxide chemotherapy cures acute promyelocytic leukemia by inducing the ubiquitylation of an oncogenic fusion protein containing promyelocytic leukemia protein (PML) subsequent to modification of PML by SUMO1 and SUMO2. We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML. Ferhi et al no...

2016
Luca Prosperini Nicola de Rossi Cristina Scarpazza Lucia Moiola Mirco Cosottini Simonetta Gerevini Ruggero Capra

BACKGROUND The monoclonal antibody natalizumab (NTZ) is a highly effective treatment for patients with multiple sclerosis (MS). However, this drug is associated with increased risk of developing Progressive Multifocal Leukoencephalopathy (PML), an opportunistic infection of central nervous system (CNS) caused by the John Cunningham polyomavirus (JCV). OBJECTIVE To describe the 12-month clinic...

Journal: :Proceedings of the ... AAAI Conference on Artificial Intelligence 2021

Partial multi-label learning (PML), which tackles the problem of prediction models from instances with overcomplete noisy annotations, has recently started gaining attention research community. In this paper, we propose a novel adversarial model, PML-GAN, under generalized encoder-decoder framework for partial learning. The PML-GAN model uses disambiguation network to identify irrelevant labels...

Journal: :Blood 2010
Ashley N Mays Neil Osheroff Yuanyuan Xiao Joseph L Wiemels Carolyn A Felix Jo Ann W Byl Kandeepan Saravanamuttu Andrew Peniket Robert Corser Cherry Chang Christine Hoyle Anne N Parker Syed K Hasan Francesco Lo-Coco Ellen Solomon David Grimwade

Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17)(q22;q21) involving the PML and RARA genes is associated with exposure to agents targeting topoisomerase II (topoII), particularly mitoxantrone and epirubicin. We previously have shown that mitoxantrone preferentially induces topoII-mediated DNA damage in a "hotspot region" within PML intron 6. To investigate mechanisms underlyin...

2016
Natalia Martín-Martín Marco Piva Jelena Urosevic Paula Aldaz James D Sutherland Sonia Fernández-Ruiz Leire Arreal Verónica Torrano Ana R Cortazar Evarist Planet Marc Guiu Nina Radosevic-Robin Stephane Garcia Iratxe Macías Fernando Salvador Giacomo Domenici Oscar M Rueda Amaia Zabala-Letona Amaia Arruabarrena-Aristorena Patricia Zúñiga-García Alfredo Caro-Maldonado Lorea Valcárcel-Jiménez Pilar Sánchez-Mosquera Marta Varela-Rey Maria Luz Martínez-Chantar Juan Anguita Yasir H Ibrahim Maurizio Scaltriti Charles H Lawrie Ana M Aransay Juan L Iovanna Jose Baselga Carlos Caldas Rosa Barrio Violeta Serra Maria dM Vivanco Ander Matheu Roger R Gomis Arkaitz Carracedo

Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggressive breast cancer. The acquisition of aggressiveness and metastatic features in breast tumours is accompanied by the elevated P...

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