نتایج جستجو برای: pneumocystis jirovecii

تعداد نتایج: 7608  

2013
Sergio L. Vargas Carolina A. Ponce Miriam Gallo Francisco Pérez J.-Felipe Astorga Rebeca Bustamante Magali Chabé Isabelle Durand-Joly Pablo Iturra Robert F. Miller El Moukthar Aliouat Eduardo Dei-Cas

BACKGROUND Pneumocystis without obvious accompanying pathology is occasionally reported in autopsied infant lungs. Its prevalence and significance are unknown. Interestingly, this mild infection induces a strong activation of mucus secretion-related genes in young immunocompetent rodents that has not been explored in infants. Excess mucus is induced by multiple airway offenders through nonspeci...

2017
Chandra S. Pingili Vel Sivapalan

PJP (Pneumocystis jirovecii) is a fungal agent by taxonomy. Ones considered a protozoan, it is now recognized as fungi based on ribosomal RNA and other gene sequence homologies, the composition of their cell walls, and structure of key enzymes. This organism generally affects immunocompromised hosts with a CD4 count <200 or <15%.Review of literature does support a rare occurrence of PJP infecti...

Journal: :Infection and immunity 2015
Waleed Elsegeiny Taylor Eddens Kong Chen Jay K Kolls

Anti-CD20 antibody therapy has been a useful medication for managing non-Hodgkin's lymphoma as well as autoimmune diseases characterized by autoantibody generation. CD20 is expressed during most developmental stages of B lymphocytes; thus, CD20 depletion leads to B-lymphocyte deficiency. As the drug has become more widely used, there has been an increase in the number of case reports of patient...

Journal: :Medical mycology 2012
Marco A Pederiva Gustavo Wissmann Vicente Friaza Rubem Morilla Carmen de La Horra Marco A Montes-Cano Luciano Z Goldani Enrique J Calderón João C Prolla

A high rate of Pneumocystis jirovecii colonization was observed in Brazilian cystic fibrosis (CF) patients (13 out of 34; 38.2%) who underwent bronchoscopy between March 2006 and August 2009 at the Hospital de Clinicas de Porto Alegre, Brazil. Bronchoalveolar lavage samples were collected from these patients and studied by nested PCR amplification of the mitochondrial gene coding for the large ...

2013
Maryam Fatemeh Sheikholeslami Javid Sadraei Parissa Farnia Mehdi Forozandeh Hamid Emadi kochak Payam Tabarsi Seyed Alireza Nadji Majid Pirestani Mohammad Reza Masjedi AliAkbar Velayati

BACKGROUND AND OBJECTIVES With increasing rate of immunodeficiency diseases in the world, opportunistic micro-organism such as Pneumocystis jirovecii (P. jirovecii) become more important. Little information is available on prevalence of this life-threatening microorganism in Iran. This study was designed to determine the colonization and the rate of active disease caused by P. jirovecii in two ...

2016
Carolina A Ponce Magali Chabé Claudio George Alejandra Cárdenas Julia Guerrero Rebeca Bustamante Olga Matos Laurence Huang Sergio L Vargas

High prevalence of Pneumocystis jirovecii dihydropteroate synthase gene 1 mutations in patients with first episode of Pneumocystis pneumonia in Santiago, 2 Chile, and their clinical response to trimethoprim-sulfamethoxazole therapy. 3 4 Carolina A Ponce, Magali Chabé, Claudio George, Alejandra Cárdenas, Luisa 5 Duran, Julia Guerrero, Rebeca Bustamante, Olga Matos, Laurence Huang, Robert 6 F Mil...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013
Philippe Hauser Meja Rabodonirina Gilles Nevez

TO THE EDITOR—We read with interest the article by Sassi et al published in Clinical Infectious Diseases [1]. They investigated Pneumocystis jirovecii genotypes involved in Pneumocystis pneumonia (PCP) outbreaks among renal transplant recipients. To that aim, they used fragment length polymorphisms of the major surface glycoprotein gene family. This work revealed that the same P. jirovecii geno...

Journal: :Journal of infection in developing countries 2015
Yogita Singh Bijay Ranjan Mirdha Randeep Guleria Shehla Khalil Ashutosh Panda Rama Chaudhry Anant Mohan Sushil Kumar Kabra Lalit Kumar Sanjay Kumar Agarwal

INTRODUCTION Pneumocystis pneumonia (PCP) is an opportunistic life-threatening infection, especially for immunocompromised individuals. A trimethoprim-sulfamethoxazole (TMP-SMX) combination is commonly used for the treatment of PCP, targeting both dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes. Several studies have already shown that polymorphisms in the DHPS gene ar...

Journal: :Emerging Infectious Diseases 2009
Marco A. Montes-Cano Magali Chabe Maria Fontillon-Alberdi Carmen de la Horra Nieves Respaldiza Francisco J. Medrano Jose M. Varela Eduardo Dei-Cas Enrique J. Calderon

If at least 1 sample was positive for M. bovis, the prevalence of bovine TB among patients would be >4.2%. However, the prevalence of M. bovis was <4.2% and confi rmed the lowlevel involvement of M. bovis in human TB in Mbarara district. These fi ndings are consistent with previous work in Uganda’s capital, Kampala, and in other African or Asian countries (2,8,9). The estimation of extrapulmona...

Journal: :Journal of clinical microbiology 2014
Christian M Parobek Linda Y Jiang Jaymin C Patel Miriam J Alvarez-Martínez Jose M Miro William Worodria Alfred Andama Serena Fong Laurence Huang Steven R Meshnick Steve M Taylor Jonathan J Juliano

Pneumocystis jirovecii is a symbiotic respiratory fungus that causes pneumonia (PcP) in immunosuppressed patients. Because P. jirovecii cannot be reliably cultured in vitro, it has proven difficult to study and gaps in our understanding of the organism persist. The release of a draft genome for the organism opens the door for the development of new genotyping approaches for studying its molecul...

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