We developed methods to assess the cancer risks by screening tests. These methods estimate the size of the high risk group adjusted for the characteristics of screening tests and estimate the incidence rates of cancer among the high risk group adjusted for the characteristics of the tests. A method was also developed for selecting the cut-off point of a screening test. Finally, the methods were...

In this paper we describe a method to measure fluid flow fields that we call Multi-Point Laser Doppler Anemometry (MPLDA). Like Doppler Global Velocimetry (DGV) and single point Laser Doppler Anemometry (LDA), the technique derives information from the Doppler shift observed when light is scattered from a moving particle and exploits the advantages of these techniques. The method retains the el...

A new method to improve the signal-to-noise ratio of single evoked potentials (EP) measurements is presented, in which, contrary to previous methods, no a priori assumptions on the signal are necessary. This method is based on the wavelets decomposition of the individual signals. A statistical thresholding is applied on the coefficients of the decomposition: we estimate whether the mean value o...

A reaction system of Michaelis-Menten enzyme on single substrate can be characterized by the initial substrate concentration before enzyme action (S0), the maximal reaction rate (Vm) and Michaelis-Menten constant (Km), besides some other required parameters. The estimations of S0, Vm and Km can be used to measure enzyme substrates, enzyme activities, epitope or hapten (enzyme-immunoassay), irre...

o system identification techniques are proposed for discriminating between the type of timing jitter that perturbs the arrival time sequence recorded for an event-based process. A univariate point process is used to characterise the observed signal activity. The first jitter identification method requires a visual inspection of an estimate of the expectation density computed for the point proce...

This paper describes the development of a four-point fully implicit block method for solving first order ordinary differential equations (ODEs) using variable step size. This method will estimate the solutions of initial value problems (IVPs) at four points simultaneously. The method developed is suitable for the numerical integration of non-stiff and mildly stiff differential systems. The perf...