BACKGROUND Following successful eradication of wild polioviruses and planned globally-coordinated cessation of oral poliovirus vaccine (OPV), national and global health leaders may need to respond to outbreaks from reintroduced live polioviruses, particularly vaccine-derived polioviruses (VDPVs). Preparing outbreak response plans and assessing potential vaccine needs from an emergency stockpile...

Objectives As efforts to control COVID-19 continue, we simulate hypothetical emergence of wild poliovirus assuming an immunologically naïve population. This differs from the current global experience with polio and serves as a model for responding future pandemics.Methods Applying established model, assume fully susceptible population polioviruses, independently introduce virus properties each ...

The emergence of vaccine-derived polioviruses (VDPVs) in patients with Primary Immunodeficiency (PID) is a threat to the polio-eradication program. In first its kind pilot study for successful screening and identification VDPV excretion among PID India, enteroviruses were assessed stool specimens 154 across India period two years. A total 21.42% tested positive enteroviruses, 2.59% (PV), wherea...

vaccines to prevent poliomyelitis have been available for 48 years, paralytic disease continues to occur in some areas, as reported by Kohler et al. 1 elsewhere in this issue of the International Journal of Epidemiology. Let us hope that by the 50th anniversary of the development of the first successful polio-myelitis vaccine all transmission of wild-type polioviruses will have ceased. The Worl...

Oral poliovirus vaccine can mutate to regain neurovirulence. To date, evaluation of these mutations has been performed primarily on culture-enriched isolates by using conventional Sanger sequencing. We therefore developed a culture-independent, deep-sequencing method targeting the 5' untranslated region (UTR) and P1 genomic region to characterize vaccine-related poliovirus variants. Error analy...

Studies on the fate of type 1 polioviruses in two common species of flies were carried out. The amount of virus in carcasses and excreta at different times was determined by the plaque assay method. Flies and their excreta remained infective for 11 days when kept at room temperature or when incubated at 36 degrees C. for 2 hours a day. Flies remained infective for 3 months when kept in hibernat...