The aim of this study was to develop celecoxib (CLX) -polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. effect different surfactants such as gelucire 44/14, poloxamer 188, 407, Ryoto sugar ester L1695, D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on nanoparticle formation dissolution well oral abs...

Aim: To evaluate the compatibility of poloxamer hydrogel as a material for an injectable intraocular lens, in vivo and in vitro. Methods: The appropriate concentration of poloxamer hydrogel was determined for injection by examining the transparency and gelling temperature of this material, assessing the lens capsule refilling technique, and studying the postoperative findings in a rabbit model....

AIM To evaluate the compatibility of poloxamer hydrogel as a material for an injectable intraocular lens, in vivo and in vitro. METHODS The appropriate concentration of poloxamer hydrogel was determined for injection by examining the transparency and gelling temperature of this material, assessing the lens capsule refilling technique, and studying the postoperative findings in a rabbit model....

Poloxamer 407 is a thermoreversible hydrogel frequently used as a carrier for polymer formulations in delayed-absorption drug studies, with limited toxicity in young mice. We gave six 24-month-old C57BL/6nia male mice each a subcutaneous injection of polylactic acid (PLA)/polyglycolic acid (PGA) copolymer biodegradable microparticles mixed with poloxamer 407 at a dose of 1.1 g/kg and 6 g/kg, re...

Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and XRPD studies demonstrated the presence of strong hydrogen bonding interaction...

Membrane-based technologies have been widely used for surface water treatment. Yet, many aspects of this technology can still be improved. This study aims to develop polyethersulfone (PES)-based phase-inverted membranes improve the morphological structure, antimicrobial properties, and performance by incorporating Poloxamer 188 patchouli oil as dope solution additives. The membrane was assessed...

The synthesis of selected polyoxyethylene-polyoxypropylene block copolymer (poloxamer) fatty acid monoesters is presented. Organotin homogeneous catalyst Sn bis(2-ethylhexanoate) effectively catalyzed the esterification reaction of (EO)-(PO)-(EO) block copolymer (poloxamer) with fatty acids. The reaction proceeded in high yield and high selectivity to monoesters. Content of diesters in final pr...

The aim of the present work was to investigate poloxamer 188 (F-68) modified montmorillonite (Mt) clay as an oral drug delivery vehicle for in vitro release of anti-inflammatory drugdiclofenac sodium (DS). The clay (Mt) was treated with F-68 and the synthesized modified Mt, (F-68-Mt) was characterized by X-Ray diffraction (XRD) studies (which confirmed the intercalation of F-68 in the clay inte...

Nanoemulsion is one the most attractive drug delivery for researchers to treat fungal diseases and getting interested in increasing solubility of low soluble drugs. The objective this research was develop a topical nanoemulsion formulation Posaconazole with intention enhance its aqueous local action. By employing High Pressure Homogenization (HPH) method, oil water formulated 0.2% cinnamon as l...