Biodegradable thermogelling copolymer hydrogels have great applicative potential in areas such as sustained drug release, gene delivery and tissue engineering. These injectable materials can be implanted in the human body with minimal surgical intervention. The thermosensitive copolymers have been incorporated with a variety of biocompatible and biodegradable components such as poly(D,L-lactic ...

The in vivo biocompatibility and biodegradation of cross-linked (co)polyethers with and without tertiary hydrogen atoms in the main chain and differing in hydrophilicity were studied by means of subcutaneous implantation in rats. After 4 days, 1 month, and 3 months postimplantation, the tissue reactions and interactions were evaluated by light microscopy (LM) and transmission electron microscop...

Electrophoretically pure human interleukin-1 (IL-1) beta was found to stimulate human fibroblasts in a monolayer culture to elaborate colony-stimulating activity (CSA). Supernatant fluids from cultures induced with increasing concentrations of IL-1 were found to stimulate colony formation of myeloid (CFU-GM), erythroid (BFU-E), and multipotent (CFU-GEMM) progenitor cells in a dose-dependent fas...

Bovine pancreatic ribonuclease A (RNase A) is a distributive endoribonuclease that catalyzes the cleavage of the P-O5' bond of RNA on the 3' side of pyrimidine residues. Here, RNase A is shown to cleave the P-O5' bond of a pyrimidine ribonucleotide faster when the substrate is embedded within a longer tract of poly(adenylic acid) [poly(A)] or poly(deoxyadenylic acid) [poly(dA)]. These data indi...

in this paper, the morphology, roughness and nano structural properties of sio2/poly vinyl pyrrolidone  synthesized with sol gel method,  characterized by using scanning electron microscopy, atomic force microscopy and gps132a techniques.the main material taken from oxide silicon with weight percentage of 20, 40, 60, 80 and from poly vinyl pyrrolidone with percentages of 80, 60, 40, 20 is synth...

as part of our ongoing interest in exploring the synthesis of antibacterial agent, we report an efficient, mild, one pot and chemoselective procedure for preparation of 3-poly (vinylbenzyl)-5,5-dimethylimidazolidine-2,4-dione as a antimicrobial agent from poly(vinylbenzyl chloride) and 5,5-dimethylhydantoin in the presence of a base in dmf as a solven. the ft-ir technique and melting point conf...

The position of a poly(A) site of eukaryotic mRNA is determined by sequence signals in pre-mRNA and a group of polyadenylation factors. To reveal rice poly(A) signals at a genome level, we constructed a dataset of 55 742 authenticated poly(A) sites and characterized the poly(A) signals. This resulted in identifying the typical tripartite cis-elements, including FUE, NUE and CE, as previously ob...

Ribonuclease H (EC 3.1.4.34) has been used to remove selectively much of the 3'-terminal poly(adenylic acid) [poly(A)] from poliovirus RNA by treating the RNA with the enzyme in the presence of poly(dT). Over 80% of the poly(A) could be removed and the residuum was found as oligo(A) stretches attached to many or all of the viral RNA molecules. Reduction of the size of the poly(A) markedly decre...

Synthesis of novel aliphatic biodegradable copolyesters namely Poly (ethylene sebacateco-butylene succinate) and Poly (ethylene sebacate-co-butylene adipate) were carried out using Poly (butylene Succinate), Poly (Butylene Adipate) and Poly (Ethylene Sebacate) in presence of Poly Phosphoric acid. Synthesis of Poly (Butylene Succinate), Poly (Butylene Adipate) and Poly (Ethylene Sebacate) were c...

• Complex formation of poly(2-ethyl-2-oxazoline) and poly(N-vinylpyrrolidone) with molecular iodine has been studied in aqueous solutions. Poly(2-ethyl-2-oxazoline) exhibits greater ability to bind compared Iodophors based on exhibited similar antimicrobial properties. Formation iodophors by interactions dissolved solutions addition potassium iodide ethanol using a range physicochemical techniq...