The dropping mechanism in the electrospinning process is elucidated. A moving jet becomes thinner at initial stage due to acceleration caused by electrostatic force. When diameter reaches a threshold, beyond which breaks into drops and daughter jets, occurs. will finally form microspheres. Effects of applied voltage, flow rate, polymer?s concentration, receptor?s distance on are theoretically a...

The objective of this study was the development of a colon-targeted microspheres which were compressed into tablets containing the non-steroidal anti-inflammatory bumadizone calcium hemihydrate. [corrected]. A 3(2) full factorial design was adopted for the evaluation of the prepared microspheres. The effect of two independent variables namely polymer type (Eudragit RS100, ethyl cellulose and ce...

Biodegradable polymer scaffolds are being extensively investigated for uses in tissue engineering because of their versatility in fabrication methods and range of achievable chemical and mechanical properties. In this study, poly(lactic-co-glycolic acid) (PLGA) was used to make various types of microspheres that were processed into porous scaffolds that possessed a wide range of properties. A h...

The objective of the study was to develop a stomach-specific drug delivery system for controlled release of clarithromycin for eradication of Helicobacter pylori (H. pylori). Floating-bioadhesive microspheres of clarithromycin (FBMC) were prepared by emulsification-solvent evaporation method using ethylcellulose as matrix polymer and Carbopol 934P as mucoadhesive polymer. The prepared microsphe...

A facile, general, and highly efficient approach to obtain narrowly dispersed molecularly imprinted polymer microspheres with multiple stimuli-responsive template binding properties in aqueous media by successive RAFT polymerization is described.

Objective: The objective of this study was to encapsulate ibuprofen in microspheres made Eudragit® RL100 as the polymer and evaluate it vitro. Methods: Microspheres were prepared by solvent evaporation method. Significant parameters evaluation microencapsulation are yield, particle size, encapsulation efficiency, swelling index, uniformity factor buoyancy. vitro release studies carried out phos...

Objective: The objective of the present work was to formulate and evaluate controlled release Octreotide acetate microspheres for subcutaneous administration for treating symptoms associated with metastatic carcinoid and vasoactive intestinal peptide tumors (VIPsecreting tumors) and acromegaly effectively and also to improve patient compliance with fewer side effects. Octreotide is a long actin...

Gastroretentive drug delivery system i.e. floating microspheres of an H2 receptor antagonist drug ‘famotidine’ was successfully prepared using combination of polymer as hydroxyl propyl ethyl cellulose K15M (HPMC K15M) and cellulose acetate via non-aqueous solvent evaporation (oil-in-water) technique. Famotidine loaded floating microsphere formulations were prepared by dissolving polymer in solv...

In the present study, an attempt was made to develop the pulsatile drug delivery of Lovastatin to the colon. Formaldehyde treated Capsule bodies were used for the preparation of pulsin caps. It was sealed with unhardened cap of the capsule. The microspheres were prepared by emulsion solvent evaporation technique. Optimized microsphere formulations were selected based on dissolution studies. Hyd...

Diclofenac sodium is a non-steroidal anti-inflammatory drug used in the treatment of arthritis. Treatment with NSAIDs is observed to have gastro intestinal side effects and the formulation of Diclofenac sodium using biodegradable and biocompatible polymer in the form of microspheres is expected to decrease GI side effects. In the present study, different microsphere formulations of Diclofenac S...