Multivalent conjugation of folic acid has been employed to target cells overexpressing folate receptors. Such polymer conjugates have been previously demonstrated to have high avidity to folate binding protein. However, the lack of a monovalent folic acid-polymer material has prevented a full binding analysis of these conjugates, as multivalent binding mechanisms and polymer-mass mechanisms are...

An experimental protocol for the realization of three-dimensional periodic metallic micro/nanostructures over large areas is presented. Simultaneous fabrication of hundreds of three-dimensional complex polymer structures is achieved using a two-photon photopolymerization (TPP) technique combined with a microlens array. Metallization of the structures is performed through the deposition of thin ...

Short Abstract 3-Formylsalicylic acid (Hfsal) covalently bound to chloromethylated polystyrene (PS) cross-linked with 5% divinylbenzene reacts with DL-alanine and L-isoleucine to give the Schiff-base tridentate ligands PS-H2fsal-DL-Ala and PS-H2fsal-L-isoleu, respectively. These anchored ligands on reaction with VOSO4 and Cu(CH3COO)2.H2O form complexes PS-[VO(fsal-DL-Ala)(H2O)], PS-[Cu(fsal-DLA...

objective: in dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. in this study, gentamicin was loaded into polylactic co-glycolic acid (plga) microspheres and its release pattern was evaluated for 20 days.   methods: in this experimental study, plga microspheres loaded with gentamycin were produced by the w/o/w method. t...

Malaprade’ introduced periodic acid for the purpose of dissociating the carbon chain of polyhydric glycols. Criegee,2 a few years later, introduced lead tetraacetate-which generally acts similarly to periodic acid-as an oxidant, particularly for the purpose of recognizing the presence of two adjacent terminal hydroxyl groups in glycosides. Fleury and Lange,” at the same time, recognized that pe...

If we could realize an autonomous polymer system driven under biological conditions by a tailor-made molecular design, human beings could create unprecedented biomimetic functions and materials such as heartbeats, autonomous peristaltic pumps, etc. In order to achieve this objective, we have investigated the molecular design of such a polymer system. As a result, we were the first to demonstrat...

the microphase separation of hydrated perfluorinated sulfonic acid membrane nafion was investigated using dissipative particle dynamics (dpd). the nafion as a polymer was modelled by connecting coarse grained beads which corresponds to the hydrophobic backbone of polytetrafluoroethylene and perfluorinated side chains terminated by hydrophilic end particles of sulfonic acid groups [1, 2]. each f...

In the present study, the lenses and ciliary bodies of 20 ostrich eyes were studied macroscopically and microscopically. The histological slides were studied after staining by hematoxylin and eosin, Verhoeff, Van Gieson, and periodic acid-Schiff (PAS). Posterior surface of lens was more convex than its anterior surface. The average lens diameter and thickness were respectively measured as 1.43 ...