Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic blocks form the corona and the core of the micelles, respectively. The presence of a nonionic water-soluble shell as well as the scale (10-100 nm) of polymeric micelles are expected to restrict their uptake by the mononuclea...

BACKGROUND As a result of its very low water solubility, propofol is generally presented as a lipid-based formulation with well-characterized limitations. METHODS Propofol (99.7%) was added directly to an aqueous solution of poly(N-vinyl-2-pyrrolidone)-block-poly(D,L-lactide)copolymers (PVP-PLA) block copolymers and stirred in order to obtain a clear solution. This formulation was filtered st...

The effective treatment of human diseases using smallmolecule and macromolecular therapeutics continues to present significant challenges to the biomedical community. In part, this stems from the physical properties of individual drug candidates, which are typically hydrophobic and poorly aqueous soluble. This necessitates the use of excipients to solubilize these compounds for delivery, which ...

Platinum-based anticancer drugs are one of the most widely used drug classes in cancer therapy. Almost half of the chemotherapy regimens used today contains a platinum drug, such as cisplatin or carboplatin. However, the drug resistance and non-specific cytotoxicity ultimately limits broader application of these drugs. Improvement of drug targeting and delivery systems are effective approaches ...

As nano-scale drug delivery systems, smart micelles that are sensitive to specific biological environment and allowed for target site-triggered drug release by reversible stabilization of micelle structure are attractive. In this work, a biocompatible and pH-sensitive copolymer is synthesized through bridging poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC) block and poly (D, L-lactide) (...

Hybrid molecular brushes (HMBs), or bottlebrush polymers, are polymeric constructs containing a linear backbone and side chains with different chemical characteristics. Hybrid-block graft copolymers (HCPs) similar to traditional HMBs, except their consists of more than one polymer. We developed facile method for the synthesis family amphiphilic, biodegradable HCPs composed two blocks: hydrophil...

Formulation of high solid load slurries is an important aspect in achieving dense, quality ceramic green body shaping by additive manufacturing techniques. To this end, the understanding and control interparticle interactions non-aqueous organic slurry systems imperative. With nanosized powders gaining increasing interest, particle stabilization long-chain polymeric dispersants undesirable due ...