It is now well appreciated that disordered proteins and domains are prevalent in eukaryotic proteomes and that disorder is critically linked with their regulation and functionality. However, our recent observations with the multi-domain protein, nucleophosmin (Npm), suggest that the biological palette of disorder is more diverse than currently understood. The N-terminal oligomerization domain o...

The objective of this work was to study the polymorphic transformation of carbamazepine from Form II to Form III in 1-propanol during seeded isothermal batch crystallization. First, the pure Form II and Form III were obtained and characterized. Then their solubilities and metastable zone limits were measured by in-situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectrosc...

The phase transition process from VO(2) (B) to VO(2) (A) was first observed through a mild hydrothermal approach, using hybrid density functional theory (DFT) calculations and crystallographic VO(2) topology analysis. All theoretical analyses reveal that VO(2) (A) is a thermodynamically stable phase and has a lower formation energy compared with the metastable VO(2) (B). For the first time, X-r...

The polymorphic phase transformation in the cocrystallization of adefovir dipivoxil (AD) and succinic acid (SUC) was investigated. Inspired by biological and biomimetic crystallization, polymeric additives were utilized to control the phase transformation. With addition of poly(acrylic acid), the metastable phase newly identified through the analysis of X-ray diffraction was clearly isolated fr...

Polymorphic digital circuits are circuits composed of polymorphic (multifunctional) as well as ordinary gates. In addition to its standard logic function (such as NAND), a polymorphic gate exhibits another logic function which is activated under a specific condition, for example, when Vdd, temperature, illumination or a special signal reaches a certain level. This paper describes existing polym...

Changes in the morphology of betulin crystals during heating at selected temperatures corresponding to polymorphic transformations were investigated. It was shown that prismatic starting form III converted into needles 120 °C after water removal, followed by III→II transformation. During further up 180 °C, whiskers I grown. Experiments on presence dicarboxylic acids, adipic or suberic showed mo...

cardiac involvement infrequently occurs in hypopituitarism, and lethal cardiac arrhythmias are rarely reported. we present a middle age female who died as a consequence of refractory ventricular arrhythmia whose medical history and previous laboratory investigation were consistent with hypopituitarism. we conclude that hypopituitarism may lead to electrocardiographic changes and malignant ventr...