نتایج جستجو برای: polymorphism genetics

تعداد نتایج: 175301  

Journal: :Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2009
Helen Naemi Honma Eduardo Mello De Capitani Aristóteles de Souza Barbeiro Daniel Botelho Costa André Morcillo Lair Zambon

OBJECTIVE To estimate and compare the frequency of CYP1A1*2A gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to lung cancer risk. METHODS The study population included 200 patients with lung cancer, and the control group consisted of 264 blood donors. Genomic DNA was obtained from peripheral blood samples. The PCR-RFLP method wa...

Journal: :Journal of the American Statistical Association 2009
Feng Guo Dipak K Dey Kent E Holsinger

The distribution of genetic variation among populations is conveniently measured by Wright's F(ST), which is a scaled variance taking on values in [0,1]. For certain types of genetic markers, and for single-nucleotide polymorphisms (SNPs) in particular, it is reasonable to presume that allelic differences at most loci are selectively neutral. For such loci, the distribution of genetic variation...

2014
Lejla Kovacevic Kristiina Tambets Anne-Mai Ilumäe Alena Kushniarevich Bayazit Yunusbayev Anu Solnik Tamer Bego Dragan Primorac Vedrana Skaro Andreja Leskovac Zlatko Jakovski Katja Drobnic Helle-Viivi Tolk Sandra Kovacevic Pavao Rudan Ene Metspalu Damir Marjanovic

Contemporary inhabitants of the Balkan Peninsula belong to several ethnic groups of diverse cultural background. In this study, three ethnic groups from Bosnia and Herzegovina - Bosniacs, Bosnian Croats and Bosnian Serbs - as well as the populations of Serbians, Croatians, Macedonians from the former Yugoslav Republic of Macedonia, Montenegrins and Kosovars have been characterized for the genet...

2015
Haijing Wang Lu Chen Binwen Ge Ye Zhang Hong Zhu Hui Zhou

Nomadic populations have played a significant role in the history of not only China but also in many nations worldwide. Because they had no written language, an important aspect in the study of these people is the discovery of their tombs. It has been generally accepted that Xiongnu was the first empire created by nomadic tribe in the 3rd century B.C. However, little population genetic informat...

Journal: :The Journal of heredity 2007
Heikki J Ryynänen Anni Tonteri Anti Vasemägi Craig R Primmer

Biallelic markers such as single nucleotide polymorphisms (SNPs) and insertion/deletion polymorphisms have become increasingly popular markers for various population genetics applications. However, the effort required to develop biallelic markers in nonmodel organisms is still substantial. In this study, we compared the estimation of various population genetic parameters (genetic divergence and...

Journal: :Genetics and molecular research : GMR 2005
Cláudia M B Carvalho Sérgio D J Pena

Several technologically sophisticated high-throughput techniques have been recently developed for the study of human single nucleotide polymorphisms and the diagnosis of point mutations in human diseases. However, there is also a need for simple and inexpensive techniques suitable for clinical services and small research laboratories. Minisequencing meets the latter requirements. It is simple, ...

Journal: :Annals of the Academy of Medicine, Singapore 2009
Hon Cheong So Eric Y H Chen Pak C Sham

The genetics of schizophrenia spectrum disorders have come a long way since the early demonstration of a substantial genetic component by family, twin and adoption studies. After over a decade of intensive molecular genetic studies, initially by linkage scans and candidate gene association studies, and more recently genome-wide association studies, a picture is now emerging that susceptibility ...

Journal: :Applied and environmental microbiology 2011
Tim H Mauchline Rachel Knox Sharad Mohan Stephen J Powers Brian R Kerry Keith G Davies Penny R Hirsch

Protein-encoding and 16S rRNA genes of Pasteuria penetrans populations from a wide range of geographic locations were examined. Most interpopulation single nucleotide polymorphisms (SNPs) were detected in the 16S rRNA gene. However, in order to fully resolve all populations, these were supplemented with SNPs from protein-encoding genes in a multilocus SNP typing approach. Examination of individ...

Journal: :Human molecular genetics 2011
Sonja I Berndt Joshua Sampson Meredith Yeager Kevin B Jacobs Zhaoming Wang Amy Hutchinson Charles Chung Nick Orr Sholom Wacholder Nilanjan Chatterjee Kai Yu Peter Kraft Heather Spencer Feigelson Michael J Thun W Ryan Diver Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Fredrick R Schumacher Geraldine Cancel-Tassin Olivier Cussenot Antoine Valeri Gerald L Andriole E David Crawford Christopher Haiman Brian Henderson Laurence Kolonel Loic Le Marchand Afshan Siddiq Elio Riboli Ruth C Travis Rudolf Kaaks William Isaacs Sarah Isaacs Kathleen E Wiley Henrik Gronberg Fredrik Wiklund Pär Stattin Jianfeng Xu S Lilly Zheng Jielin Sun Lars J Vatten Kristian Hveem Inger Njølstad Daniela S Gerhard Margaret Tucker Richard B Hayes Robert N Hoover Joseph F Fraumeni David J Hunter Gilles Thomas Stephen J Chanock

Previous genome-wide association studies have identified two independent variants in HNF1B as susceptibility loci for prostate cancer risk. To fine-map common genetic variation in this region, we genotyped 79 single nucleotide polymorphisms (SNPs) in the 17q12 region harboring HNF1B in 10 272 prostate cancer cases and 9123 controls of European ancestry from 10 case-control studies as part of th...

2014
Genovefa Kolovou Georgia Ragia Vana Kolovou Constantinos Mihas Niki Katsiki Ioannis Vasiliadis Sophie Mavrogeni Vassiliki Vartela Anna Tavridou Vangelis G. Manolopoulos

BACKGROUND One of the promises of human genetics is individualized therapy. Therefore, we evaluated the impact of CYP3A5 gene polymorphism on the effectiveness of simvastatin (a HMG-CoA reductase inhibitor). METHODS Patients (n = 191) with hypercholesterolemia were treated with simvastatin for at least 6 months and were genotyped for the CYP3A5 polymorphism. RESULTS The frequency of CYP3A5 ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید