1 Department of Medicine, Jawaharlal Nehru Medical College, Sawangi, Meghe-440 022, Maharashtra, India. 2 Department of Pediatrics, Jawaharlal Nehru Medical College, Sawangi, Meghe-440 022, Maharashtra, India. 3 Department of Medicine, Jawaharlal Nehru Medical College, Sawangi, Meghe-440 022, Maharashtra, India. [email protected] Abstract Diabetic polyneuropathy is one of the more comm...

BACKGROUND Patients with diabetic polyneuropathy (DPN) are often confronted with ulceration of foot soles. Increased plantar pressure under the forefoot has been identified as a major risk factor for ulceration. This study sets out to test the hypothesis that changes in gait characteristics induced by DPN related muscle weakness are the origin of the elevated plantar pressures. METHODS Three ...

OBJECTIVE To investigate risk factors for diabetic peripheral polyneuropathy and their correlation with the quantified severity of nerve dysfunction in patients with diabetes mellitus (DM). METHODS A total of 187 diabetic patients with clinically suspected polyneuropathy (PN) were subclassified into 2 groups according to electrodiagnostic testing: a DM-PN group of 153 diabetic patients withou...

474 February 2014 P OSTOPERATIVE residual curarization is common after the use of muscle relaxants and may compromise patient outcome after general anesthesia.1–3 The incidence of postoperative residual curarization can be reduced by adequate neuromuscular block reversal and quantitative neuromuscular monitoring.4,5 However, in patients with severe pathologies of the peripheral nervous system, ...

OBJECTIVE To evaluate efficacy and safety of lacosamide compared with placebo in painful diabetic polyneuropathy. RESEARCH DESIGN AND METHODS Diabetic patients with at least moderate neuropathic pain were randomized to placebo or lacosamide 400 (in a slow or standard titration) or 600 mg/day over 6-week titration and 12-week maintenance periods. Primary efficacy criterion was intra-individual...

Rational treatment of diabetic polyneuropathy depends upon establishing its cause, which is at present unknown. A number of animal models of diabetes have been examined and although abnormalities are detectable in the peripheral nervous system they do not duplicate the degenerative neuropathy encountered in the human. The relevance of these abnormalities is therefore uncertain, although they ma...

Background: Scorpion sting envenomation generally causes treatable local and systemic effects; however, in rare cases, the victims might experience sequels in end organs such as central nervous system. In the present paper, a case of relatively self-limiting demyelinating polyneuropathy following a Butidae sting is presented and the possible mechanisms are discussed.  Case Presentation: A 19-y...

Polyneuropathy means a lot of diseases affecting peripheral nerves showing roughly the same areas on both sides of the body, featuring weakness, numbness, and burning pain [1]. Pathogenesis causing polyneuropathy usually begins in the hands and feet and progresses to the arms and legs [1]. Sometimes it can involve other parts of the body such as the autonomic nervous system. Uncountable causes ...

OBJECTIVE To compare the natural history of familial transthyretin amyloid polyneuropathies (FAP) due to the Val30Met, Ser77Tyr, and Ile107Val mutations in France with the classical Portuguese Val30Met FAP. METHODS We compared 84 French patients with a control group of 110 Portuguese patients carrying the Val30Met mutation also living in France, all referred to and followed at the French Nati...