Diabetics with end-stage renal disease (ESRD) exhibit abnormal life span of erythrocytes, and thus, HbAlc is not necessarily a good indicator for blood glucose control. The present study was conducted to reaffirm this point and determine whether glycated albumin (GA) can be used instead of HbAlc. The following three groups of patients with diabetes served as subjects: 49 predialysis patients wi...

The Diabetes Control and Complications Trial (DCCT) was a major clinical study con­ ducted from 1983 to 1993 and funded by the National Institute of Diabetes and Digestive and Kidney Diseases. The study showed that keeping blood glucose levels as close to normal as possible slows the onset and pro­ gression of the eye, kidney, and nerve damage caused by diabetes. In fact, it demonstrated that a...

Background: Pomegranate seed oil and its main constituent, punicic acid, have been shown to decrease plasma glucose and have antioxidant activity. The objective of the present study was to examine the effects of pomegranate seed oil on rats with type 2 diabetes mellitus. Method: Six groups (n=8 each) of male Sprague-Dawley rats, comprising a control, a diabetic (induced by Streptozocin and Nico...

background: pancreatic islet transplantation has emerged as a promising treatment for type i diabetes. however, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. it has been shown that local delivery of vascular endothelial growth factor (vegf) could accelerate transplanted islet revasculariz...

Background & Aim: Diabetes mellitus is a chronic disease characterized by elevated blood glucose levels and disturbances in carbohydrate, fat and protein metabolism. The objective of the present investigation was to evaluate the therapeutic efficacy of Morus alba leaves in an animal model of diabetes. Martial & Methods: 30 adult male Wistar strain rats (200-250 g) were divided randoml...

BACKGROUND Management of type 2 diabetes remains a challenge in Africa. The objective of this study was to evaluate the prevalence and predictors of poor glycemic control in patients with type 2 diabetes living in sub-Saharan. PATIENTS AND METHODS This was a cross-sectional study involving 1267 people (61% women) with type 2 diabetes (mean age 58 years) recruited across health facilities in C...

background: physical exercise and herbal treatment with antioxidant property induce a favorable effect on glucose metabolism in diabetic patients. the aim of the present study was to investigate the effects of resistance training combined with green tea extract consumption on blood glucose and lipid profile in diabetic rats. forty male wistar diabetic rats aged 5 months and weights 290 ± 20 wer...

Combination therapy consisting of biphasic insulin aspart 30 bid with metformin provide better glycaemic control in obese patients with diabetes mellitus type 2. In our study, patients who were treated with 2550 mg of metformin, administered in three daily doses had poor glycaemic control. Three months after switching from metformin therapy to treatment with biphasic insulin aspart 30 + metform...

in this investigation, diabetes was induced in adult male sprague-dawley rats by single intraperitoneal injection of streptozotocin (stz) at 45 mg kg-1 of body weight. a group comprised of 8 diabetic rats was treated with metformin at 100 mg kg-1 of body weight for reducing the elevated blood glucose level. the results revealed that, in the untreated diabetic rats, the body and testicular weigh...

OBJECTIVE In this study, we evaluated the efficacy of sibutramine in combination with hypoglycemic drugs in obese type 2 diabetic women whose glucose levels were poorly regulated. RESEARCH DESIGN AND METHODS Female patients with type 2 diabetes, poorly controlled glucose levels, and HbA(1c) >8% were randomly assigned to one of two groups. In addition to their prescribed hypoglycemic agents (m...