Background: Cytochrome P450 2C19 (CYP2C19) is important in metabolism of wide range of drugs. CYP2C19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (URM). Distribution of this variant allele has not been well studied worldwide. The aim of present study was to investigate allele and genotype frequencies of CYP2C19*17 ...

Estimation of Distribution Algorithms (EDAs) are implemented mainly by the three steps: selecting the promising subset from the current population, modeling the distribution of the selected population and sampling from the estimated model. Modeling and sampling are key steps of EDAs. They are also research topic of copula theory to represent the multivariate joint distribution by a copula and t...

Severe adverse events (SAEs) following ivermectin treatment may occur in people harbouring high Loa loa microfilarial (mf) densities. In the context of mass ivermectin distribution for onchocerciasis control in Africa, it is crucial to define precisely the geographical distribution of L. loa in relation to that of Onchocerca volvulus and predict the prevalence of heavy infections. To this end, ...

The two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), is an economically important pest of ornamental plant in Iran. The population abundance and spatial distribution were studied on five Rosa cultivars including Maroussia, Wendela, Elderado, Wenedetta, and Hot Lady during two growing seasons of 2011 and 2012 in greenhouse. The k parameter, index of dispersion, Lloyd’s m...

in this paper, we obtain  bayesian prediction intervals as well as bayes predictive estimatorsunder square error loss for generalized order statistics when the distribution of the underlying population belongs to a family which includes several important distributions.

Iran is located in an area with high earthquake risk. There are over 20 active faults with length of 500 km and also densely populated parts of the country have been rendered vulnerable to strong earthquakes. However, existence of eight faults of the main faults of Iran along with at least 18 faults with length of more than 100 km in Kerman province have turned the place into one of the riskies...

Hearing Loss (HL) represents high genetic heterogeneity with an incidence of almost 1 out of 500 newborns in most populations. Approximately half of the cases have a genetic basis that most of them are autosomal recessive non-syndromic (ARNSHL) with DFNB1-related defect in many worldwide populations. Given the heterogeneity of the trait together with the unique infrastructure of Iranian populat...