Poly-L-lactide/β-tricalcium phosphate (PLLA/β-TCP) porous scaffold fabricated by freeze shrinking/particulate leaching was studied. The scaffold was immersed into simulated body fluid (SBF) for 1, 2, 3 and 4 weeks and analyzed by the SEM, XRD and FT-IR spectroscopy. The ability of inducing Ca-P formation was compared among the scaffolds with different content of βTCP. SEM shows a typical featur...

OBJECTIVE To investigate a scaffold-enhanced, light-activated bioadhesive technique as a substitute for sutures in ophthalmic surgery. CLINICAL RELEVANCE Suture use in ophthalmic surgery is technically demanding and time consuming and may be associated with serious complications such as inadvertent ocular penetration, which can result in retinal detachment and endophthalmitis. Bioadhesive sur...

In current therapeutic strategies, bone defects are filled up by bone auto- or allografts. Since they are limited by insufficient availability and donor site morbidity, it is necessary to find an appropriate alternative of synthetic porous bone materials. Because of their osteoconductive characteristics, ceramic materials like tricalciumphosphate (TCP) are suitable to fill up bone defects. Anot...

Poly(lactide-co-glycolide) (PLGA) is used in many biomedical applications because it is biodegradable, biocompatible, and FDA approved. PLGA can also be processed into porous tissue scaffolds, often through the use of organic solvents. A static light scattering experiment showed that 75/25 PLGA is well solvated in acetone and methylene chloride, but forms aggregates in chloroform. This led to a...

A new bulky pyrene-derived elongated cross-shaped organic scaffold was successfully incorporated into a highly porous, noninterpenetrated square-grid copper(II)-organic framework material with the unprecedentedly huge dimensions of 25.5 x 25.5 A(2), while the layer-to-layer NH...N interaction leads to a unique hydrogen-bonded 6(4).8(2)-nbo net.

Porous nanospheres have a wide range of applications such as in catalysis, separation and controlled delivery. Among these nanospheres, syntheses and applications of porous silica nanospheres have been investigated extensively. Uniform porous silica nanospheres can be synthesized using a modified Stöber method. In the present study, porous silica spheres were prepared in the pre-formed emulsion...

Several characteristics of a novel PLGA/Merwinite scaffold were examined in the present study to evaluate the possible applications in bone tissue regeneration. Physical and mechanical properties, as well as degradation behavior and in vitro bioactivity of porous scaffolds produced by solvent casting and particle leaching technique were also characterized. Results showed that incorporation of m...

The aim of this study was to develop a porous chitosan scaffold with long-acting drug release as an artificial dressing to promote skin wound healing. The dressing was fabricated by pre-freezing at different temperatures (-20 and -80 °C) for different periods of time, followed by freeze-drying to form porous chitosan scaffolds with different pore sizes. The chitosan scaffolds were then used to ...

BACKGROUND The aim of this study was to evaluate osteogenesis ability of CAD/CAM porous zirconia scaffolds enriched with hydroxy apatite used to augment large boney defects in a dog model. METHODS Surgical defects were made bilaterally on the lower jaw of 12 Beagle dogs. Cone beam CT images were used to create three dimensional images of the healed defects. Porous zirconia scaffolds were fabr...

Current clinical therapies for critical-sized bone defects (CSBDs) remain far from ideal. Previous studies have demonstrated that engineering bone tissue using mesenchymal stem cells (MSCs) is feasible. However, this approach is not effective for CSBDs due to inadequate vascularization. In our previous study, we have developed an injectable and porous nano calcium sulfate/alginate (nCS/A) scaff...