In eight patients with cirrhosis of the liver and portal hypertension an intravenous infusion of lysine vasopressin induced a rapid increase in the plasma level of the fibrinolytic proenzyme plasminogen activator. In contrast, triglycyl lysine vasopressin (glypressin; GVP), in a dose known to lower portal venous pressure, produced no fibrinolytic response. This lack of fibrinolytic response rep...

In 1933, John McMichael was awarded a gold medal by the University of Edinburgh for his M.D. thesis. This was entitled 'The pathology of hepatolienal fibrosis' and was published in an abridged form in 1934 in the Journal of Pathology and Bacteriology. It was a masterly account of the pathological changes associated with portal hypertension. Pathological changes in spleen and portal vasculature ...

BACKGROUND Circulating miRNA-34a is increased in blood of patients with different liver diseases when compared to healthy controls. However, the origin of miRNA-34a and its possible relationship with hemodynamics and outcome in cirrhotic patients with portal hypertension is unknown. We analyzed the levels of miRNA-34a in cirrhotic patients with severe portal hypertension. METHODS We included ...

In 1933, John McMichael was awarded a gold medal by the University of Edinburgh for his M.D. thesis. This was entitled 'The pathology of hepatolienal fibrosis' and was published in an abridged form in 1934 in the Journal of Pathology and Bacteriology. It was a masterly account of the pathological changes associated with portal hypertension. Pathological changes in spleen and portal vasculature ...

In a previous paper (1) it was shown that digitalis in dogs caused a fall in venous pressure at the time when the minute volume flow of blood was diminished. This fall in venous pressure, and hence in return flow of blood to the heart, was correlated with a peripheral vasocontrictor action of the digitalis. It was indicated that constriction of the hepatic veins was the major factor in causing ...

We investigated the systemic and regional hemodynamic effects of early crystalloid infusion in an experimental model of septic shock induced by intravenous inoculation with live Escherichia coli. Anesthetized dogs received an intravenous infusion of 1.2 x 10(10) cfu/kg live E. coli in 30 min. After 30 min of observation, they were randomized to controls (no fluids; N = 7), or fluid resuscitatio...

PURPOSE To determine whether an increase in tumor angiogenesis facilitates intravasation of colorectal epithelial cells, we compared intratumoral microvessel counts with the presence of circulating colorectal epithelial cells in the portal venous blood from patients with colorectal carcinomas. EXPERIMENTAL DESIGN Circulating colorectal epithelial cells were detected by a reverse transcription...

OESOPHAGEAL VARICES are generally secondary to portal hypertension and are therefore usually associated with obstruction to the portal circulation within the liver as in cirrhosis or in the portal vein itself. Thus, according to the site of obstruction, portal hypertension is usually classified as intrahepatic or extrahepatic in type (Whipple, 1945). However, an increasing number of cases of po...

Transesophageal echocardiography was used to evaluate venous bubbles produced in nine anesthetized dogs following decompression from 2.84 bar after 120 min at pressure. In five dogs a pulsed Doppler cuff probe was placed around the inferior vena cava for bubble grade determination. The transesophageal echo images demonstrated several novel or less defined events. In each case where the pulmonar...

Portal hypertension can be caused by any disease interfering with blood flow at any level within the portal venous system. According to anatomic location, the diseases causing portal hypertension are classif ied as prehepatic (diseases involving the splenic, mesenteric, or portal veins), intrahepatic (acute and chronic l iver diseases), or posthepatic (diseases interfering with the venous outfl...