Posaconazole, ravuconazole, and voriconazole are new triazole derivatives that possess potent, broad-spectrum antifungal activity. We evaluated the in vitro activity of these investigational triazoles compared with that of itraconazole and amphotericin B against 239 clinical isolates of filamentous fungi from the SENTRY Program, including Aspergillus spp. (198 isolates), Fusarium spp. (7 isolat...

ABSTRACT Posaconazole exhibits in-vitro activity against Candida glabrata and krusei. Epidemiological cut-off values set by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) Clinical Laboratory Standards Institute (CLSI) are 1/1 0.5/0.5 mg/L, respectively, but clinical breakpoints have not been established to date. This study explored pharmacodynamics (PD) of posaconazole ...

The Antifungal Susceptibility Testing method of the European Committee on Antimicrobial (EUCAST-AFST) is a reference technique for determination Minimum Inhibitory Concentration (MIC) antifungals Aspergillus fumigatus. However, it time-consuming and requires expertise. Micronaut-AM (M-AM) fast, simple, time-saving, ready-to-use new colorimetric using an indicator (resazurin) to facilitate visua...

Over the years, the spectrum of patients at risk for invasive fungal disease (IFDs) has expanded. This is a result of the aging of the general population, progress in supportive care allowing clinicians to perform a higher number of aggressive and curative treatments, the introduction of new drugs in clinical practice (i.e. monoclonal antibodies, TNFinhibitors), and the increasing number of tra...

OBJECTIVES The aim of this study is to determine the efficacy and safety of posaconazole in patients with underlying renal impairment. Patients and methods We analysed the efficacy and safety of posaconazole in patients with renal impairment in a post hoc subanalysis of a Phase 3, multicentre, open-label trial in patients with invasive fungal infections (IFIs). In the Phase 3 study, 330 patient...

Interest in antifungal therapeutic-drug monitoring has increased due to studies demonstrating associations between concentrations and outcomes. We reviewed the antifungal drug concentration database at our institution to gain a better understanding of achievable triazole drug levels. Antifungal concentrations were measured by high-performance liquid chromatography (HPLC), ultraperformance liqui...

MALDI-TOF MS can rapidly identify microorganisms to the species level and may be able to detect antimicrobial resistance. We evaluated the ability of this technology to detect triazole resistance in Candida species.35 C. albicans, 35 C. glabrata, and 37 C. tropicalis strains were exposed to fluconazole, voriconazole, or posaconazole at two different concentrations plus a drug-free control: a mi...

Isavuconazole is a new broad-spectrum triazole with a favorable pharmacokinetic and safety profile. We report the MIC distributions for isavuconazole and 111 isolates of Candida (42 Candida albicans, 25 Candida glabrata, 22 Candida parapsilosis, 14 Candida tropicalis, and 8 Candida krusei isolates), as determined by Clinical and Laboratory Standards Institute (CLSI) and European Committee on An...

Aim Current prescribing in our trust, the absence of a guideline and licensing for prophylactic posaconazole children under 12 years, is based on paper by Boonsathorn et al. 2018 1 The purpose this audit to evaluate extent which monitoring oral prescribed within paediatric inpatient population line with published recommendations. Targets were 100% patients dosed as recommended ; trough concentr...