experimental and epidemiological evidences implicate the involvement of oxygen derived radicals in the pathogenesis of cancer development. oxygen derived radicals are able to cause damage to membranes, mitochondria and macromolecules including proteins, lipids and dna. accumulation of dna damages has been suggested to contribute to carcinogenesis. it would, therefore, be advantageous to pinpoin...

(Received for publication, November 30, 1957) Cancerous ascitic fluids with primary seat in stomach were condensed together, precipitated with alcohol and boiled with changes of 80% ethanol. The solutions given were also condensed and precipitated with alcohol, and after taking up in water, electrodialyzed. The deposit occurring here was fractionally precipitated from water with alcohol and wit...

Swarnabhasma, an Ayurvedic preparation containing Calotropis gigantea R. Br. (Asclepiadaceae) is extensively used by Ayurvedic physicians for treatment of diabetes mellitus, bronchial asthma, rheumatoid arthritis and nervous disorders. In the present study, we report the effect of chloroform extracts of Calotropis gigantea leaf and flower on free radical scavenging activity, and lipid profile i...

results the results of ifn-γ, il-4 production against antigens, epitopes, and recombinant catalase by t-cells were compared for better understanding of epitope efficiency. conclusions the current research demonstrated that epitope sequence stimulates cellular immune responses effectively. in addition, increased safety and potency as well as a reduction in time and cost were advantages of this m...

Reactive oxygen species (ROS) are important in the initiation and promotion of cells to neoplastic growth. In this context, cigarette smoke exposure, the primary risk factor in lung cancer development, leads to high levels of ROS within the human airway. Although well-equipped with an integrated antioxidant defense system consisting of low-molecular weight antioxidants such as glutathione and i...

Streptococcus pyogenes (group A streptococcus [GAS]), a catalase-negative gram-positive bacterium, is aerotolerant and survives H2O2 exposures that kill many catalase-positive bacteria. The molecular basis of the H2O2 resistance is poorly known. Here, we demonstrate that serotype M49 GAS lacking the Rgg regulator is more resistant to H2O2 and also decomposes more H2O2 than the parental strain. ...

The lack of safe potable water in many developing countries puts their citizens at high risk of contracting water-borne diseases. Solar water disinfection (SODIS) offers a simple, inexpensive method of sanitizing water by utilizing the ultraviolet-A radiation (UV-A) from sunlight to generate highly reactive, bacteriocidal forms of oxygen known as reactive oxygen species (ROS). However, previous...