OBJECTIVE This study compared the effect of clozapine and haloperidol on positive and negative symptoms of schizophrenia and in patients with high levels of negative symptoms or the deficit syndrome. METHOD Patients were participants in a 15-site double-blind, random-assignment Veterans Administration trial comparing clozapine (N=205) and haloperidol (N=217) in hospitalized patients with refr...

BACKGROUND Some studies find that parents of children with Down's syndrome may experience symptoms of depression, while other studies find that parents adapt well. This study aimed to clarify this variability in adaptive strength by investigating a stress-coping model to explain depressive symptoms and positive affect. METHOD Questionnaires were completed by 553 parents of children (aged 0-18...

Negative symptoms are still a major obstacle in the recovery of schizophrenic patients. Many attempts to develop novel drugs affecting negative symptoms of schizophrenia have yielded insignificant results. This study evaluates the effects of bromocriptine, a dopamine agonist, on negative symptoms of schizophrenia utilizing a placebo-controlled crossover double-blind clinical trial. Methodology:...

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Animal Assisted Therapy (AAT) using dogs is an effective treatment for positive and negative symptoms for adult inpatient schizophrenics. STUDY DESIGN: Systematic review of 3 articles published in English in peer reviewed journals between 2005-2009 DATA SOURCES: Two randomized controlled trials and one allocati...