BACKGROUND Early differential diagnosis between acute bacterial and viral meningitis is problematic. We aimed to investigate whether the detection of lipocalin 2, a protein of the acute innate immunity response, may be used as a marker for acute bacterial meningitis. METHODS Transgenic mice expressing the human transferrin were infected by intraperitoneal route and were imaged. Cerebrospinal ...

Abstract Introduction The use of ESCC and SINS scoring in the planning surgery Neurosurgical patients is something mutual habit standard practise. This project looks at outcomes referred to centre via Metastatic Spinal Cord Compression (MSCC) referral, relevance surgical as well post-operative between neurosurgical orthopaedic surgeons when treating same cohort patients. Method We looked a tert...

background: acute bacterial meningitis is among serious infections of the central nervous system (cns). the early diagnosis and empiric antibiotic treatments have led to a reduction in morbidity and mortality rates. pcr and the enzymatic digestion of 16s rdna fragment following the pcr by universal primers led up fast and sensitive determination. the aims of the present study was to improve our...

BACKGROUND The epidemiology of pneumococcal meningitis in the African 'meningitis belt' is poorly studied. In order to ensure an effective vaccination strategy and post-vaccination surveillance, we examined the serotype distribution patterns of pneumococcal meningitis in Niger over the period 2003-2011. METHODS Cerebrospinal fluid (CSF) samples were collected from different health facilities ...

Introduction: Staphylococcus aureus causing isolate central nervous system (CNS) infection is rare. It is mostly related to either neurosurgical intervention or previous local or systemic infection rather than spontaneous isolated infection in adults. Case Report: We report a case of a previously healthy 19­year­old male with no risk factors of Staphylococcus aureus infection, who was found to ...

brain substance, produced by a variety of pyogenic organisms. Infection originates via extension from adjacent foci or by metastasis through blood stream or thorough septic emboli from other sources of intravascular infection. Although Enterococcus spp account for one of the majority causes of brain abscesses, the true incidence of each of Enterococcus spp causing brain abscess is not known. Mo...

Considerable progress has been made in the last decade towards better understanding of the optimal clinical use of colistin. It has become evident that higher intravenous (iv) colistin methanesulfonate (CMS) doses are important, probably with the addition of a loading dose in critically ill patients. Higher CMS doses lead to increased risk of nephrotoxicity, which seems reversible in most cases...