BACKGROUND Epithelial ovarian carcinoma is a deadly disease characterized by overt peritoneal metastasis. Individual cells and multicellular aggregates, or spheroids, seed these metastases, both commonly found in ascites. Mechanisms that foster spheroid attachment to the peritoneal tissues preceding formation of secondary lesions are largely unknown. METHODS Cell culture models of SKOV-3, OVC...

OBJECTIVE To describe the safety and efficacy of open laparoscopic access for the primary trocar using modified Hasson's technique for laparoscopic surgery in children. METHODS All 100 laparoscopic procedures performed at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between January 1999 and April 2001 using modified Hasson's technique were prospectively evaluated. They wer...

purpose: to compare clear corneal incision and scleral tunnel incision in terms of intraocular pressure (iop), post-operative inflammation, induced astigmatism, and corneal edema in phacoemulcification. methods: this non-controlled clinical trial was conducted on 78 eyes with senile cataract. a clear corneal incision was made in 40 eyes and a scleral tunnel incision was made in 38 eyes. all eye...

BACKGROUND The aim of our study is to analyze survival, treatment-related morbidity, and safety in our experience of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. METHODS Sixty-four patients were treated. Survival curves were calculated according to the Kaplan-Meier method. Univariate and multivariate analyses were done, and Cox's proportional hazard model was used to i...

Peritoneal dissemination is a frequent metastatic route for cancers of the ovary and gastrointestinal tract. Tumour cells metastasize by attaching to and invading through the mesothelial cell (MC) monolayer that lines the peritoneal cavity. Metastases are influenced by carcinoma-associated fibroblasts (CAFs), a cell population that derives from different sources. Hence, we investigated whether ...

A new edition is most welcome. When the book appeared in 1937 it was well in advance of anything then in print. There is again a great deal of recent work assimilated into the body of the various chapters. Among the names of contributors are many new ones,some of which have been prominent in the journals during the last 8 years. We miss the name of Homans and his beautiful article on thrombosis...

Aim of this paper is to report a case of extrusion of Ventriculo peritoneal shunt tube through anus in a one year female child ( k/c/o dandy walker malformation ) treated with placement of ventriculo peritoneal shunt for post operative hydrocephalus after excision of Subtorcular occipital meningocoel. The exact cause of such extrusion is not known. Unusual migration of distal catheter tip of VP...

BACKGROUND Formation of intra-abdominal adhesions depends, in part, on the activity of serine proteinases. Matrix metalloproteinases (MMP) are required for epithelialization of skin wounds but their involvement in mesothelialization of peritoneal wounds and in adhesion pathogenesis is not known. Early tumor necrosis factor-alpha (TNF-alpha) levels have been proposed to reflect propensity to adh...

BACKGROUND Peritoneal dissemination is one of the main causes of death in gastric cancer patients. Transforming growth factor-beta1 (TGF-β1), one of the most potent fibrotic stimuli for mesothelial cells, may play a key role in this processing. The purpose of this study is to elucidate the effects of TGF-β1 on regulation of gastric cancer adhesion to mesothelial cells. METHODS Peritoneal tiss...