Purpose We develop a quantitative bioluminescence assay for in vivo longitudinal monitoring of inflammation in animal models of uveitis. Methods Three models of experimental uveitis were induced in C57BL/6 albino mice: primed mycobacterial uveitis (PMU), endotoxin-induced uveitis (EIU), and experimental autoimmune uveitis (EAU). Intraperitoneal injection of luminol sodium salt, which emits li...

PURPOSE To demonstrate the demographic, anatomic, and diagnostic classification of patients with uveitis seen in a tertiary care center in central Virginia. METHODS Retrospective chart review of patient demographics, disease characteristics, and disease severity-related outcomes (therapies, visual outcomes, and complications) from 1984 to 2014. RESULTS There were 491 patients (644 eyes) wit...

<b>Background:</b> Uveitis is one of the most frequent ophthalmologic manifestations in rheumatology. Uveal inflammation can underlie a systemic inflammatory rheumatic disease (SIRD) approximately 30% cases with significant burden on quality life since it represents cause blindness up to 20% Western countries. <b>Methods:</b> In this review, we provide comprehensive over...

PURPOSE Chemokines are important inflammatory mediators that play a crucial role in uveitis. Polymorphisms in chemokine genes can alter the expression of these genes in the inflammatory cells, which, in turn, can affect the clinical phenotype of the disease. The purpose of this study was to identify polymorphisms in chemokine genes that can predict visual outcome in patients with immune-mediate...

purpose: to report the visual outcomes and complication of one-stage surgery for management of uveitic cataracts associated with posterior segment disease. methods: in this retrospective interventional case series, 19 eyes of 19 patients with posterior segment involvement due to chronic uveitis underwent sutureless scleral tunnel incision phacoemulsification combined with total vitrectomy using...

PURPOSE To report the causes, clinical features, and outcomes of infectious uveitis in patients managed in a mid-Atlantic tertiary care center. METHODS Retrospective, observational study of infectious uveitis patients seen at the University of Virginia from 1984 to 2014. RESULTS Seventy-seven of 491 patients (15.7%) were diagnosed with infectious uveitis (mean age 58 years, 71.4% female, 76...

Aim To report the clinical features, investigations, management, and outcome in typical cases of Vogt-Koyanagi-Harada Syndrome (VKH) in a tertiary eye care center in South India. Materials and methods Retrospective interventional case series of VKH patients. Results Seventy-one eyes of 36 patients (age range 12-68 years) were included. Anatomical diagnoses were posterior uveitis (15 eyes) and p...