Momordica charantia (bitter melon) is commonly known as vegetable insulin, but the mechanisms underlying its hypoglycemic effect remain unclear. To address this issue, the effects of bitter melon extracts on postprandial glycemic responses have been investigated in rats. An aqueous extract (AE), methanol fraction (MF) and methanol insoluble fraction (MIF) were prepared from bitter melon. An ora...

BACKGROUND Previous studies have demonstrated that postprandial hyperglycemia attenuates brachial artery flow-mediated dilation (FMD) in prediabetic patients, in diabetic patients, and even in normal subjects. We have previously reported that postprandial hyperinsulinemia also attenuates FMD. In the present study we evaluated the relationship between different degrees of postprandial attenuatio...

It is known that the ingestion of glucose alone causes a greater increase in plasma glucose levels than ingestion of the same amount of glucose given with other nutrients. Since physiological plasma concentrations of cholecystokinin (CCK) prolong gastric emptying, it is proposed that after a meal, CCK may modify plasma glucose levels by delaying glucose delivery to the duodenum. To evaluate the...

Abstract: The number of people with diabetes is expected to rise from the current estimated 150 million to 220 million in 2010 and 300 million in 2025, and 90% is Type 2 diabetes or non-insulin dependant diabetes mellitus (NIDDM). Voglibose, one of the most important α-glucosidase inhibitors, delays the digestion and absorption of carbohydrates, thereby inhibiting postprandial hyperglycemia and...

H yperglycemia is due to a dysregulation in the complex mechanisms implicated in glucose homeostasis. Chronic hyperglycemia, as measured by hemoglobin A1c (HbA1c), is a key risk factor for the development of microvascular and macrovascular complications, which in turn negatively influence the prognosis of patients with diabetes. Several studies have shown that acute hyperglycemia can add to the...

Postprandial hyperglycemia is well established as a major risk factor for prediabetes and type 2 diabetes. However, postprandial hyperlipidemia, no definitive criteria exist, fasting values of lipids lipoproteins had limited efficacy estimating lipidemia. In the present study, we performed fat-ingestion test aimed to propose indices lipoprotein metabolism. Methods: Healthy young Japanese women ...

Autoimmune dysglycemia syndrome (ADS) is a rare condition that presents as episodes of hypoglycemia well hyperglycemia and classified insulin autoimmune (IAS) type B resistance (TBIR). Autoimmunity plays key role in the pathogenesis this disorder, evidenced by presence autoantibodies against endogenous or receptor, its association with rheumatologic disorders. Treatment usually includes glycemi...