Oligomeric forms of the Parkinson’s disease-causing protein a-synuclein are suspected to mediate neurodegeneration, but the mechanisms are not understood. The present study of Shrivastava et al (2015) provides a fresh insight into this old mystery. a-Synuclein oligomers are shown by a combination of top state-of-the-art biochemical and super-resolution microscopy methods to sequester the neuron...

in this study, an efficient and facile technique for preparing graphene oxide in suspension and powder forms was presented based on a modification on hummers' method followed by an additional ultrasonic process. the method involved the provision of graphene oxide from graphite by reaction of potassium permanganate and sulfuric acid with stabilizing the medium complex. furthermore, this stu...

thermal behavior of various solid feldspars are different, namely those of bivalent cations show no change in the distribution of al and si atoms, whereas feldspars of univalent cations become more disordered with raising temperature. in the latter case al atoms migrate from the sites they occupe at low temperatures and interchange positions with the si atoms. at high temperatures (but still be...

Fast and selective transport of water through cell membranes is facilitated by water channels. Water channels belonging to the major intrinsic proteins (MIPs) family have been found in all three domains of life, Archaea, Bacteria, and Eukarya. Here we show that Chlorella virus MT325 has a water channel gene, aqpv1, that forms a functional aquaglyceroporin in oocytes. aqpv1 is transcribed during...

Potassium-competitive acid blockers (P-CABs) are highly safe and active drugs targeting H+,K+-ATPase to cure acid-related gastric diseases. In this study, we for the first time investigate the interaction mechanism between the protonated form of P-CABs and human H+,K+-ATPase using homology modeling, molecular docking, molecular dynamics and binding free energy calculation methods. The results e...

microglia is a type of glial cell located throughout the central nervous system (cns), which is sensitive to cns injury and disease. responsibility of microglia as the resident macrophage cells for injuries suggests that these cells have the potential to act as diagnostic markers of disease beginning or progression. function of microglia is strongly synchronized by the microenvironment of brain...

This research was conducted to study potassium buffering potential behavior in some burned soils of Baweza – Mosul and Zawita- Dohuk , north Iraq. Potassium forms the phenomenon were studied by using thermodynamic parameters according quantity- intensity ratio (Q/I) at 298 oK) The main results could be summarized as follows A great affection for firing processto cause a high availability lost l...

An iodine biofortification experiment was conducted by applying potassium iodate fertilizer in soil and foliar form chitosan complex forms to investigate the growth, yield, quality uptake of shivam hybrid tomato Palaviduthi series Coimbatore region. Soil fertilization alone resulted lower fruits because is susceptible high volatilization less phytoavailability also yield poor fruits. When were ...

A simple, selective, rapid, precise and economical reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of paracetamol and diclofenac potassium from pharmaceutical formulation. The method was carried out on a Phenomenex LUNA C18 (25 cm x 4.6 mm i.d., 5 μ) column with a mobile phase consisting of acetonitrile: sodium dihydrogen ortho pho...

Introduction Iodine is an essential nutrient found in seawater, seafood, and iodine-enriched food, such as iodized table salt. The most common forms of iodine in diet are iodide and iodate, with additional iodo-organic compounds providing a small fraction of bioavailable iodine. Iodine deficiency affects thyroid hormone production and leads to developmental diseases, goiter, and paralysis.1 Tab...