Thorough QT studies are becoming a necessary part of the clinical profile of existing and investigational new drugs. The E14 guidelines mandate performing a thorough QT study on any non antiarrythmic drug to ensure that the drug does not produce a QT prolongation effect before it can be approved and marketed. The cost involved in running a thorough QT study is substantial and an adverse outcome...

In this paper, the implementation of Virtual Power Plant as a means to coordinate the use of distributed resources for different control objectives by TSO and DSO is described. In order to illustrate the concept, a range of illustrative studies demonstrating the application of VPP concept on a real 11 kV system in Brixton will be presented, using data from the Low Carbon London project. The stu...

muscle contracts, releasing the tension on the suspensory ligaments. Habitat loss Alien species Pollution Over-exploitation Disease Species Affected by Cause Page 748 Mader Inquiry Into Life, VII. In sickness or in option. The preceding power-supply circuit, with external pass transistor, has a maximum transistor dis-sipation of 20 watts for an unregulated input of 15 volts (10V drop.

This paper reviews and puts in context some of our recent work on stochastic volatility modelling for financial economics. Here our main focus is on: (i) the relationship between subordination and stochastic volatility, (ii) OU based volatility models, (iii) exact option pricing, (iv) realised power variation and realised variance, (v) building multivariate models.

The requirements that are placed on today’s grid are changing. Traditional power flows from power stations to the nearest big city are giving way to more complex patterns. Growing consumption and power trading mean that power must increasingly be transported over large distances. Growth in the use of renewable sources is placing a strain on the system because generation is often located in remo...

PG Student, Dept of EEE, Annamacharya Institute of Technology & Sciences, Rajampet, Andhra Pradesh, India Assistant Professor, Dept of EEE, Annamacharya Institute of Technology & Sciences, Rajampet, India Professor & Head of the Department, Dept of EEE, Annamacharya Institute of Technology & Sciences. E-Mail: [email protected] Abstract:This paper presents a dynamic modeling and control stra...

Sub-threshold leakage and process-induced variations in bulk-Si technology limit the scaling of SRAM into sub-32 nm nodes. New device architectures are being considered to improve control Vt and reduce short channel effects. Among the likely candidates, FinFETs are the most attractive option because of their good scalability and possibilities for further SRAM performance and yield enhancement t...

This paper explores the deterministic transistor reordering in low-voltage dynamic BiCMOS logic gates, for reducing the dynamic power dissipation. The constraints of load driving (discharging) capability and NPN turn-on delay for MOSFET reordered structures has been carefully considered. Simulations shows significant reduction in the dynamic power dissipation for the transistor reordered BiCMOS...

This paper models firms’ choices between alternative means of presenting information, and the effects of different presentations on market prices when investors have limited attention and processing power. In a market equilibrium with partially attentive investors, we examine the effects of alternative: levels of discretion in pro forma earnings disclosure, methods of accounting for employee op...