• Distribution 2: Pr(0) = Pr(50) = Pr(100) = 1/3. Both have the same expectation: 50. But the first is much less “dispersed” than the second. We want a measure of dispersion. • One measure of dispersion is how far things are from the mean, on average. Given a random variable X , (X(s) − E(X)) measures how far the value of s is from the mean value (the expectation) of X . Define the variance of ...

Progesterone and its interaction with nuclear progesterone receptors (PR) PR-A and PR-B play a critical role in the regulation of female reproductive function in all mammals. However, our knowledge of the regulation and possible cellular function of PR protein isoforms in the fallopian tube and uterus in vivo is still very limited. In the present study, we revealed that equine chorionic gonadot...

In Arabidopsis, NPR1 mediates the salicylic acid (SA)-induced expression of pathogenesis-related (PR) genes and systemic acquired resistance (SAR). Here, we report the identification of another component, CPR 6, that may function with NPR1 in regulating PR gene expression. The dominant CPR 6-1 mutant expresses the SA/NPR1-regulated PR genes (PR-1, BGL 2, and PR-5) and displays enhanced resistan...

BACKGROUND In Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT), patients with non-left bundle branch block (LBBB; including right bundle branch block, intraventricular conduction delay) did not have clinical benefit from cardiac resynchronization therapy with defibrillator (CRT-D). We hypothesized that baseline PR interval modulates clinical r...

OBJECTIVES To obtain evidence for dose response and to extend evidence of safety and efficacy for B lymphocyte depletion in rheumatoid arthritis. METHODS Twenty two patients with rheumatoid arthritis received a total of 29 treatments with five different combinations of rituximab (RTX), cyclophosphamide (CP), and/or high dose prednisolone (PR) on an open basis as follows; cohort I: RTX 1400 mg...

INTRODUCTION Pulmonary rehabilitation (PR) is an established component of COPD management. The lack of exercise performance improvement (EPI) in severely dyspnoeic patients (Medical Research Council [MRC] score 5) has been questioned. The data on the gender impact on EPI after PR remain scarce. OBJECTIVES The impact of dyspnea severity on PR outcomes was investigated and a question was raised...

Background and Aims: Post exercise proteinuria and increased urinary Gamma-Glutamyl transferase (GGT) levels can be indicative of exercise-induced renal damage. The aim of this investigation was to study the effect of one session of intensive training on renal tubular injury markers and compare their values to those 6 hours after training, for evaluating tubular damage after intensive ...

Purpose: The luminal subtype of breast cancer has heterogeneous biological characteristics with respect to the expression estrogen receptor (ER), progesterone (PR), human epidermal growth factor-2 (HER2), and Ki-67. We analyzed B subcategorized by PR identified clinically relevant prognostic factors.Methods: collected clinical pathologic data 247 patients (stage 1-4) who were diagnosed subtype,...

This report describes the thermochemistry, proton-coupled electron transfer (PCET) reactions and self-exchange rate constants for a set of bis-benzimidazolate-ligated [2Fe-2S] clusters. These clusters serve as a model for the chemistry of biological Rieske and mitoNEET clusters. PCET from [Fe2S2((Pr)bbim)((Pr)bbimH)](2-) (4) and [Fe2S2((Pr)bbim)((Pr)bbimH2)](1-) (5) to TEMPO occurs via concerte...