We describe distinct patterns of histone methylation during human cell cycle progression. Histone H4 methyltransferase activity was found to be cell cycle-regulated, consistent with increased H4 Lys 20 methylation at mitosis. This increase closely followed the cell cycle-regulated expression of the H4 Lys 20 methyltransferase, PR-Set7. Localization of PR-Set7 to mitotic chromosomes and subseque...

It has been claimed that speakers distinguish between phonemically-identical initial syllables that differ in morphological structure, but the phonetic details are poorly understood. Five SSBE speakers read scripted dialogues containing words with such syllables, half with true prefixes (Pr) e.g. mistimes, displease, and half with pseudo-prefixes (PsPr) e.g. mistakes, displays. Each word occurr...

Conversely, suppose all the low-order Fourier coe cients are 0. Since D̂(100 0) = Pr[x1 = 0] Pr[x1 = 1] = 0, x1 is equally likely to be 0 or 1, and similarly for the other xi's. Now let pa1a2 = Pr[x1x2 = a1a2]. Since x1, x2, and x1 x2 are all unbiased, we get the equations p00 + p01 = p00 + p10 = p00 + p11 = 1=2. Furthermore, p00 + p01 + p10 + p11 = 1. From these equations, we deduce that all of...

Re-replicating G2 cells (cyclin B1, red; EdU, green). Image courtesy of E. Julien. An Epigenetic License to Replicate Chromosome replication needs to occur once and only once during the cell cycle to produce daughter cells with accurate genetic content. Licensing of replication origins is one form of DNA synthesis regulation, in which origins are loaded with pre-replication complex (RC) protein...

[reaction: see text]. A novel convergent approach to fully functionalized ring C allocolchicinoids is developed which is based on the benzannulation reaction of Fischer carbene complexes with alkynes. The efficacy of this strategy was established with the conversion of bromide 1a (R1 = Me, R2 = H) to the biaryl phenol 3a (R = Me, R(L) = Pr, R(S) = H) via the carbene complex 2a. Bromide 1b (R1 =...

In many robotic applications, manipulation planning for an object free to slide on a surface is an import; oblem. Physical analysis of the object's motion is made difficult by the absence of information about 1 stribution of support of die object, and of the resulting frictional forces. This paper describes a n iproach to the analysis of sliding motion. The instantaneous motion of the object ca...

Proof of Proposition 1. Occupational Choice As given in equation (5), the individual’s utility from choosing a particular occupation, U(τi, wi, ǫi), is proportional to (w̄igǫi) β 1−η , where w̄ig ≡ wih̄igs φi i (1− si) 1−η β /τig. The solution to the individual’s problem, then, involves picking the occupation with the largest value of w̄igǫi. To keep the notation simple, we will suppress the g subs...

Cet article propose un panorama des inégalités d’émissions de gaz à effet serre (GES) entre les ménages français. Il présente manière détaillée et critique conventions méthodologiques retenues pour le calcul « émissions ménages », présupposés qui accompagnent. Le principe d’attribution g&#...